1-Methylguanidine hydrochloride
1-Methylguanidine hydrochloride structure
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Common Name | 1-Methylguanidine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 21770-81-0 | Molecular Weight | 109.55800 | |
| Density | 1.22 g/mL at 20 °C(lit.) | Boiling Point | 72 °C | |
| Molecular Formula | C2H8ClN3 | Melting Point | -20 °C | |
| MSDS | Chinese USA | Flash Point | 65 °F | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.
J. Pharm. Pharm. Sci. 17(4) , 475-84, (2015) Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs. The effect of d... |
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Structure and dynamics of a salt-bridge model system in water and DMSO.
J. Chem. Phys. 142 , 212436, (2015) We study the interaction between the ions methylguanidinium and trifluoroacetate dissolved in D2O and dimethylsulfoxide with linear infrared spectroscopy and femtosecond two-dimensional infrared spectroscopy. These ions constitute model systems for the side c... |
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In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells.
J. Pharm. Pharmacol. 67(2) , 170-7, (2015) It has been reported that intestinal urate excretion is increased at chronic kidney disease (CKD) state. In this report, whether uremic toxins are involved in the upregulation of intestinal breast cancer resistance protein (BCRP), an intestinal urate exporter... |
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Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Bioorg. Med. Chem. Lett. 22(7) , 2444-9, (2012) From an initial lead 1, a structure-based design approach led to identification of a novel, high-affinity iminohydantoin BACE1 inhibitor that lowers CNS-derived Aβ following oral administration to rats. Herein we report SAR development in the S3 and F' subsit... |