SRPIN340

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Names

[ CAS No. ]:
218156-96-8

[ Name ]:
SRPIN340

[Synonym ]:
3,4-Dipropoxy-3-cyclobuten-1,2-dion
SR protein phosphorylation inhibitor 1
4-Pyridinecarboxamide (N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]
4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-
squaric acid dibutyl ester
N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide
1,2-di-n-propoxy-cyclobutenedione
di-n-propyl squarate
(SRPIN)340 N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
N4-[2-piperidino-5-(trifluoromethyl)phenyl]isonicotinamide
3-Cyclobutene-1,2-dione,3,4-dipropoxy
SRPIN-340
SRPIN340

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
395.9±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H18F3N3O

[ Molecular Weight ]:
349.350

[ Flash Point ]:
193.3±27.9 °C

[ Exact Mass ]:
349.140198

[ PSA ]:
45.23000

[ LogP ]:
4.15

[ Appearance of Characters ]:
light yellow solid

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.578

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-piperidino-5-(trifluoromethyl)aniline
  • ISONICOTINOYL CHLORIDE HYDROCHLORIDE

DownStream

Articles

Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma.

Br. J. Cancer 111(3) , 477-85, (2014)

Current therapies for metastatic melanoma are targeted either at cancer mutations driving growth (e.g., vemurafenib) or immune-based therapies (e.g., ipilimumab). Tumour progression also requires angi...

Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization.

Mol. Vis. 19 , 536-43, (2013)

To investigate the applicability of serine/arginine-rich protein kinase (SRPK)-specific inhibitor, SRPIN340, for attenuation of choroidal neovascularization (CNV) formation using a mouse model.Laser p...

Dysregulation of splicing proteins in head and neck squamous cell carcinoma.

Cancer Biol. Ther. 17 , 219-29, (2016)

Signaling plays an important role in regulating all cellular pathways. Altered signaling is one of the hallmarks of cancers. Phosphoproteomics enables interrogation of kinase mediated signaling pathwa...


More Articles

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 1-(3-Aminooxolan-3-yl)ethan-1-one
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide