1,4-Benzodioxan-6-amine

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Names

[ CAS No. ]:
22013-33-8

[ Name ]:
1,4-Benzodioxan-6-amine

[Synonym ]:
6-Amino-1,4-benzodioxane
3,4-Ethylenedioxyaniline
2,3-Dihydrobenzo[b][1,4]dioxin-6-amine
6-Amino-1,4-benzodioxan
2,3-dihydro-1,4-benzodioxin-6-amin
1,4-Benzodioxan-6-amine
MFCD00006824
EINECS 244-718-4
6-amino-2,3-dihydro-1,4-benzodioxin

Chemical & Physical Properties

[ Density]:
1.231 g/mL at 25 °C(lit.)

[ Boiling Point ]:
116-118°C 3mm

[ Melting Point ]:
29-31 °C(lit.)

[ Molecular Formula ]:
C₈H₉NO₂

[ Molecular Weight ]:
151.16300

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
151.06300

[ PSA ]:
44.48000

[ LogP ]:
1.62120

[ Vapour Pressure ]:
0.0017mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.599(lit.)

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R38

[ Safety Phrases ]:
S26-S37/39-S36/37

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29329995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,3-Dihydro-6-nitro-1,4-benzodioxin
1,4-Benzodioxan
7-NITRO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YLAMINE
6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine
1,2-Benzenediol

DownStream

3,4-ethylenedioxyiodobenzene
4-CHLORO-6,7-DIMETHYLENEDIOXYQUINAZOLINE
1-(2,3-dihydro-1,4-benzodioxin-6-yl)piperazine
2-Chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl) acetamide
9-methyl-2,3-dihydropyrano[2,3-g][1,4]benzodioxin-7-one
6,7-DIHYDRO-1H-[1,4]DIOXINO[2',3':4,5]BENZO[D]IMIDAZOLE-2-THIOL
5H-(2)benzopyrano(3,4-g)(1,4)benzodioxin-5-one
N-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL-2-(ETHYLAMINO)ACETAMIDE HYDROCHLORIDE
2,3-Dihydrobenzo[b][1,4]dioxin-6-ol
2,3-dihydro-1,4-benzodioxin-6-yl isocyanate

Preparation

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis of Novel Functionalized 4-Aza-2,3-Didehydropodophyllotoxin Derivatives with Potential Antitumor Activity.

J. Heterocycl. Chem. 47(6) , 1275-1282, (2010)

Novel arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yiel...

2, 3-Dihydrodioxin [2, 3-b] acridin-11 (6H)-one. Karolak-Wojciechowska J, et al.

Acta Crystallogr. C 54(11) , 1689-90, (1998)

1,4-Benzodioxan-6-propionamide (5CI)
1,4-Benzodioxan-6-carboxylic acid,7-cyano- (6CI)
1,4-Benzodioxan-6-carboxylic acid,2-methyl- (6CI)
(1,4-benzodioxan-6-ylmethyl)guanidinium sulphate (2:1)
6-amino-2,2,3,3-tetrafluoro-1,4-benzodioxan
α-(1,4-benzodioxan-6-yl)-2,4-dihydroxy-5-ethylacetophenone
2-Cyclohexyl-6-methyl-1,2,3,4-tetrahydroquinolin-3-ol
2-{1-[2-(Dimethylamino)-1,3-thiazol-5-yl]cyclobutyl}acetic acid
2-(2-Methoxypropan-2-yl)-6-methyl-1,2,3,4-tetrahydroquinolin-3-ol
6-Methyl-2-(oxan-3-yl)-1,2,3,4-tetrahydroquinolin-3-ol
3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-4-oxobutanoic acid
3-Fluoro-2-(2-fluoro-3-hydroxyphenyl)benzaldehyde
4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-[(3R)-3-hydroxypyrrolidin-1-yl]-5-oxopentanoic acid
(2S)-2-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-N-methylpentanamido}propanoic acid
3-(Aminomethyl)-3-(3-ethylphenyl)cyclobutan-1-ol
3-[N-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-enamido]butanoic acid

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