6-Hydroxymelatonin
Suppliers
Names
[ CAS No. ]:
2208-41-5
[ Name ]:
6-Hydroxymelatonin
[Synonym ]:
6-HydroxyMelatonin
6-Hydroxy Melatonin
N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
Chemical & Physical Properties
[ Density]:
1.266g/cm3
[ Boiling Point ]:
564.7ºC at 760mmHg
[ Melting Point ]:
172-175ºC
[ Molecular Formula ]:
C13H16N2O3
[ Molecular Weight ]:
248.27800
[ Flash Point ]:
295.3ºC
[ Exact Mass ]:
248.11600
[ PSA ]:
74.35000
[ LogP ]:
1.95160
[ Vapour Pressure ]:
2.35E-13mmHg at 25°C
[ Index of Refraction ]:
1.627
[ Storage condition ]:
Refrigerator
[ Water Solubility ]:
alcohol: soluble
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AC3607000
- CHEMICAL NAME :
- Acetamide, N-(2-(6-hydroxy-5-methoxyindol-3-yl)ethyl)-
- CAS REGISTRY NUMBER :
- 2208-41-5
- BEILSTEIN REFERENCE NO. :
- 0483231
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C13-H16-N2-O3
- MOLECULAR WEIGHT :
- 248.31
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 8 mg/kg
- SEX/DURATION :
- male 20 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 33,618,1985
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H351
[ Precautionary Statements ]:
P281
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
22-40
[ Safety Phrases ]:
36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
AC3607000
[ HS Code ]:
2933990090
Synthetic Route
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Mol. Cell. Endocrinol. 404 , 1-8, (2015)
Melatonin and its metabolites including 6-hydroxymelatonin (6(OH)M), N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) and 5-methoxytryptamine (5MT) are endogenously produced in human epidermis. This...
J. Pineal Res. 59 , 448-54, (2015)
The cloning of the gene encoding melatonin 2-hydroxylase (M2H), which is responsible for the synthesis of 2-hydroxymelatonin, has expanded the study of melatonin metabolism in plants. Kinetic analysis...
J. Pineal Res. 58(3) , 343-51, (2015)
Although melatonin biosynthetic genes from plants have been cloned, the melatonin catabolism mechanisms remain unclear. To clone the genes responsible for melatonin metabolism, we ectopically expresse...