Chloromethyl chloroformate

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Names

[ CAS No. ]:
22128-62-7

[ Name ]:
Chloromethyl chloroformate

[Synonym ]:
chloromethoxycarbonyl chloride
EINECS 244-793-3
chloromethyl chlorocarbonate
chloroformic acid chloromethyl ester
Carbonochloridic acid, chloromethyl ester
Chloromethyl chloroformate
MFCD00077688
Chlorocarbonate de chlorométhyle
1-chloromethyl chloroformate
chlormethylchlorocarbonat
Chloromethyl carbonochloridate

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
107.9±13.0 °C at 760 mmHg

[ Melting Point ]:
<-20ºC

[ Molecular Formula ]:
C2H2Cl2O2

[ Molecular Weight ]:
128.942

[ Flash Point ]:
25.5±15.2 °C

[ Exact Mass ]:
127.943184

[ PSA ]:
26.30000

[ LogP ]:
1.14

[ Vapour Pressure ]:
26.5±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.432

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H331

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2745 6.1/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

Synthetic Route

Preparation


Articles

Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes.

Bioorg. Med. Chem. 8(7) , 1719-25, (2000)

A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, a...

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media.

Arch. Pharm. (Weinheim) 340(1) , 32-40, (2007)

Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carb...

Water soluble cyclosporine monomethoxy poly(ethyleneglycol) conjugates as potential prodrugs.

Arch. Pharm. Res. 27(6) , 662-9, (2004)

The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbon...


More Articles


Related Compounds

  • Chloromethyl 3-((tert-butoxycarbonyl)amino)propanoate
  • Chloromethyl pivalate
  • chloromethyl-(dichloro-fluoro-methyl)-sulfide
  • CHLOROMETHYL PHENYL SULFONE
  • (chloromethyl)(2-oxo-2-phenylethyl)mercury
  • chloromethyl naphthalen-2-yl carbonate
  • Pentan-2-yl tetrahydrofuran-2-carboxylate
  • (R)-2-(5-Ethylthiophen-2-yl)propan-1-ol
  • Ethyl 2-(1-methoxycyclopropyl)acetate
  • 4-Bromo-5H-pyrido[3,2-b]indole
  • (2R)-Methyl 2-amino-2-(tetrahydrofuran-3-yl)acetate
  • 2-Bromo-6-(1-methylcyclopropyl)naphthalene
  • 2-(5-(tert-Butyl)furan-2-yl)-1H-benzo[d]imidazole
  • 8-Bromo-[1,2,4]triazolo[4,3-b]pyridazine
  • 2-Fluoro-5-azaspiro[3.5]nonane
  • 4-((4-((6-Acetoxyhexyl)oxy)benzoyl)oxy)-3-chlorophenyl 4-((6-(acryloyloxy)hexyl)oxy)benzoate
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