1-Piperidinamine

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Names

[ CAS No. ]:
2213-43-6

[ Name ]:
1-Piperidinamine

[Synonym ]:
1-aminopiperidine
N-Piperidylamine
piperidin-1-ylamine
1-Piperidinamine
1-Piperidinamine (9CI)
1-amino-piperidine
PIPERIDINE,1-AMINO
EINECS 218-666-8
N-Aminopiperidine
Pentamethylenehydrazine Piperidin-1-ylamine
N,N-pentamethylenehydrazine
1-piperidinylamine
piperidin-1-amine
MFCD00006489

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
146.9±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C5H12N2

[ Molecular Weight ]:
100.162

[ Flash Point ]:
36.1±0.0 °C

[ Exact Mass ]:
100.100044

[ PSA ]:
29.26000

[ LogP ]:
-0.28

[ Vapour Pressure ]:
4.5±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.486

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM4165000
CHEMICAL NAME :
Piperidine, 1-amino-
CAS REGISTRY NUMBER :
2213-43-6
BEILSTEIN REFERENCE NO. :
0383565
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H12-N2
MOLECULAR WEIGHT :
100.19
WISWESSER LINE NOTATION :
T6NTJ AZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
3 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 91,199,1981

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R10;R20/21/22;R34

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
TM4165000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Piperidine
  • 1-Nitrosopiperidine
  • 2,2,4,4-tetramethyl-7-oxa-3,20-diazadispiro[5.1.11.2]-henicosan-21-one
  • Potassium carbonate
  • allyl bromide
  • Carbamic acid,1-piperidinyl-, ethyl ester (9CI)
  • 1-Piperidinecarboxamide
  • N-piperidin-1-ylacetamide
  • 1,5-Dibromopentane

DownStream

  • 2-chloro-5-nitro-N-piperidin-1-ylbenzamide
  • bis(1-piperidyl)diazene
  • Dibenzyldiselane
  • α-(Piperidinoimino)acetophenone
  • surinabant
  • 1-Nitrosopiperidine
  • 1,1-dinitro-N-(piperidin-1-yl)methanimine
  • Piperidine
  • 1-Piperidinamine,N-[[2-(5-nitro-2-furanyl)-4-thiazolyl]methylene]-
  • 1-Piperidinamine,N-[[2-(5-nitro-2-thienyl)-4-thiazolyl]methylene]-

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION.

J. Biol. Chem. 290 , 20313-24, (2015)

Historically, type II topoisomerases have yielded clinically useful drugs for the treatment of bacterial infections and cancer, but the corresponding enzymes from malaria parasites remain understudied...

Inhibition of metabolism--mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma cells (line P815).

Adv. Exp. Med. Biol. 136 Pt B , 1067-75, (1981)

Aerial oxidation of hydrazines to nitrosamines.

Environ. Mol. Mutagen. 17(1) , 59-62, (1991)

When 1,1-dimethylhydrazine and N-aminopiperidine were deliberately exposed to air substantial amounts of the corresponding carcinogenic nitrosamines were formed. Unoxidized samples of 1,1-dimethylhydr...


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Related Compounds

  • 1-PIPERIDINAMINE,2-METHYL
  • 1-piperidinamine,4-ethynyl
  • 3-Methoxy-1-piperidinamine
  • 4-Methoxy-1-piperidinamine
  • 1-Piperidinamine,N-methylene
  • 1-Piperidinamine,4,4-difluoro
  • 8-chloro-2-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propanoyl)-3,4-dihydro-1H-dipyrido[1,2-a:4',3'-d]pyrimidin-11(2H)-one
  • N-(1-(benzofuran-2-yl)propan-2-yl)isobutyramide
  • N-(2-(benzofuran-2-yl)-2-methoxyethyl)-2-methoxyacetamide
  • N-(1-((3-chloro-4-methoxyphenyl)sulfonyl)azetidin-3-yl)pyrimidin-2-amine
  • 3-cyclopentyl-N-(4,4-difluorocyclohexyl)propanamide
  • 4-(2-fluoroethyl)-N-(3-methoxypropyl)piperazine-1-carboxamide
  • 3-iodo-6-methyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazine
  • 3-Iodo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazine
  • 4-cyclohexyl-1,3-dimethyl-4,5-dihydro-1H-1,2,4-triazol-5-one
  • 1,3-dimethyl-4-[(oxolan-2-yl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one