Carbimazole

Suppliers

Names

[ Name ]:
Carbimazole

[Synonym ]:
Carbimazolum
Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate
EINECS 244-854-4
Carbimazol
Carbimazole
Neo-Thyreostat
3-Methyl-2-thioxo-2,3-dihydro-imidazol-1-carbonsaeure-aethylester
1-Methyl-3-carbethoxy-2-thioglyoxalone
1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester
CG 1
Thyrostat
ethyl 3-methyl-2-thionoimidazoline-1-carboxylate
Carbethoxymethimazole
3-methyl-2-thioxo-2,3-dihydro-imidazole-1-carboxylic acid ethyl ester
ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate
3-methyl-1-ethoxycarbonylimidazoline-2-thione
Carbinazole
2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic Acid Ethyl Ester
Athyromazole
1-Ethoxycarbonyl-3-methyl-2-thioxo-4-imidazoline
MFCD00027421
Neomercazole
1-Ethoxycarbonyl-3-methyl-2-thio-4-imidazoline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
240.4±23.0 °C at 760 mmHg

[ Melting Point ]:
124°C

[ Molecular Formula ]:
C₇H₁₀N₂O₂S

[ Molecular Weight ]:
186.232

[ Flash Point ]:
99.2±22.6 °C

[ Exact Mass ]:
186.046295

[ PSA ]:
68.25000

[ LogP ]:
0.34

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.612

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2441000

CHEMICAL NAME :: 4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-, ethyl ester

CAS REGISTRY NUMBER :: 22232-54-8

BEILSTEIN REFERENCE NO. :: 0144339

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H10-N2-O2-S

MOLECULAR WEIGHT :: 186.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 703 mg/kg/17W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Sense Organs and Special Senses (Ear) - tinnitus

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 25 mg/kg/6W-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 23 mg/kg/5W-I

TOXIC EFFECTS :: Liver - jaundice, cholestatic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1 mg/kg/1D-I

TOXIC EFFECTS :: Liver - jaundice, other or unclassified

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 1 gm/L

REFERENCE :: CHINAG Chemistry and Industry (London). (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.1- 1923- Volume(issue)/page/year: (21),847,1980

Safety Information

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S36/37/39

[ RIDADR ]:
3335

[ RTECS ]:
NJ2441000

[ HS Code ]:
2922499915

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Gingival pain: an unusual side effect of ziprasidone.

BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)

The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...

A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.

BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)

The pharmacokinetics of methimazole in a novel lipophilic formulation administered transdermally to healthy cats.

N. Z. Vet. J. 62(4) , 208-13, (2014)

To determine the pharmacokinetics of a novel lipophilic formulation of transdermal methimazole compared to oral carbimazole.Healthy cats received 5 mg carbimazole orally every 12 hours for 13 treatmen...