Tempol

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Names

[ Name ]:
Tempol

[Synonym ]:
4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl,TEMPOL
HYDROXY-TEMPO
(4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyl)oxidanyl
4-Hydroxy-TEMPO Free Radical
EINECS 218-761-4
Tempol
(4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
4-Oxypiperidol
Tetramethylpiperidino-N-oxyl
TMPN
4-Hydroxy-2,2,6,6-tetramethylpiperidine N-oxide
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical
Tanol
4-Hydroxy-TEMPO
4-Hydroxy-2,2,6,6-tetramethylpiperidinoxyl
4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl free radical
4-Hydroxy-2,2,6,6-te
NR-I
4-hydroxy-2,2,6,6-tetramethyl piperidinyloxy,free radical
4-hydroxy-2,2,6,6-tetramethylpiperidinoxy radical
nr1
2,2,6,6-Tetramethyl-4-piperidinol 1-oxyl
2,2,6,6-Tetramethyl-4-hydroxypiperidinooxy
4-Hydroxy-2,2,6,6-tetramethylpiperidinooxyl
nitroxyl2
OH-Tempo, 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical
2,2,6,6-Tetramethyl-4-hydroxy-1-piperidinyloxy radical
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy,free radical
4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl
Tetramethylpiperidinol N-oxyl
2,2,6,6-Tetramethyl-4-hydroxypiperidinooxy radical
4-OH-TEMPO
4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine
4-hydroxy-2,2,6,6-tetramethyl-piperidinyloxy
1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-
4-Hydroxy-2,2,6,6-tetramethylpiperidinooxy radical
4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxy
MFCD00006478

Chemical & Physical Properties

[ Density]:
1.187 g/cm3

[ Boiling Point ]:
269ºC

[ Melting Point ]:
69-71 °C(lit.)

[ Molecular Formula ]:
C₉H₁₈NO₂*

[ Molecular Weight ]:
172.24

[ PSA ]:
23.47000

[ LogP ]:
1.28370

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN8991000

CHEMICAL NAME :: Piperidinooxy, 4-hydroxy-2,2,6,6-tetramethyl-

CAS REGISTRY NUMBER :: 2226-96-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H18-N-O2

MOLECULAR WEIGHT :: 172.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1053 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 24 umol/plate

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 251,393,1986

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
TN8991000

[ HS Code ]:
29333999

Precursor & DownStream

Precursor

DownStream

6-Hydroxy-2-naphthaldehyde
Methacrylic anhydride
4-hydroxy-tempo
2,2,6,6-TETRAMETHYL-1-(1-PHENYLETHOXY)-&
1-methoxy-2,2,6,6-tetramethylpiperidin-4-ol
1-cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-ol
1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-ol

Customs

[ HS Code ]: 29333999

Articles

NADPH oxidase 2-derived superoxide downregulates endothelial KCa3.1 in preeclampsia.

Free Radic. Biol. Med. 57 , 10-21, (2013)

Endothelial dysfunction is associated with KCa3.1 dysfunction and contributes to the development of hypertension in preeclampsia. However, evidence of endothelial KCa3.1 dysfunction in the vascular sy...

Gastrokine 1 inhibits the carcinogenic potentials of Helicobacter pylori CagA.

Carcinogenesis 35(11) , 2619-29, (2014)

Helicobacter pylori CagA directly injected by the bacterium into epithelial cells via a type IV secretion system, leads to cellular changes such as morphology, apoptosis, proliferation and cell motili...

Organic Radical Contrast Agents Based on Polyacetylenes Containing 2,2,6,6-Tetramethylpiperidine 1-Oxyl (TEMPO): Targeted Magnetic Resonance (MR)/Optical Bimodal Imaging of Folate Receptor Expressing HeLa Tumors in Vitro and in Vivo(a).

Macromol. Biosci. 15 , 788-98, (2015)

Nitroxides have great potential as magnetic resonance imaging (MRI) contrast agents for tumor detection. Polyacetylenes(PAs) containing 2,2,6,6-tetramethyl-piperidine oxyl (TEMPO) and poly(ethylene gl...

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