Tempol
Tempol structure
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Common Name | Tempol | ||
|---|---|---|---|---|
| CAS Number | 2226-96-2 | Molecular Weight | 172.24 | |
| Density | 1.187 g/cm3 | Boiling Point | 269ºC | |
| Molecular Formula | C9H18NO2* | Melting Point | 69-71 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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NADPH oxidase 2-derived superoxide downregulates endothelial KCa3.1 in preeclampsia.
Free Radic. Biol. Med. 57 , 10-21, (2013) Endothelial dysfunction is associated with KCa3.1 dysfunction and contributes to the development of hypertension in preeclampsia. However, evidence of endothelial KCa3.1 dysfunction in the vascular system from women with preeclampsia is still lacking. Therefo... |
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Gastrokine 1 inhibits the carcinogenic potentials of Helicobacter pylori CagA.
Carcinogenesis 35(11) , 2619-29, (2014) Helicobacter pylori CagA directly injected by the bacterium into epithelial cells via a type IV secretion system, leads to cellular changes such as morphology, apoptosis, proliferation and cell motility, and stimulates gastric carcinogenesis. We investigated ... |
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Organic Radical Contrast Agents Based on Polyacetylenes Containing 2,2,6,6-Tetramethylpiperidine 1-Oxyl (TEMPO): Targeted Magnetic Resonance (MR)/Optical Bimodal Imaging of Folate Receptor Expressing HeLa Tumors in Vitro and in Vivo(a).
Macromol. Biosci. 15 , 788-98, (2015) Nitroxides have great potential as magnetic resonance imaging (MRI) contrast agents for tumor detection. Polyacetylenes(PAs) containing 2,2,6,6-tetramethyl-piperidine oxyl (TEMPO) and poly(ethylene glycol) were synthesized via metathesis polymerization of the... |
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Cytoprotective effects of grape seed extract on human gingival fibroblasts in relation to its antioxidant potential.
PLoS ONE 10 , e0134704, (2015) Cytoprotective effects of short-term treatment with grape seed extract (GSE) upon human gingival fibroblasts (hGFs) were evaluated in relation to its antioxidant properties and compared with those of a water-soluble analog of vitamin E: trolox (Tx). GSE and T... |
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Determination of Intermolecular Interactions Using Polarization Compensated Heteronuclear Overhauser Effect of Hyperpolarized Spins.
Anal. Chem. 87 , 10982-7, (2015) The nuclear Overhauser effect (NOE) has long been used as a selective indicator for intermolecular interactions. Due to relatively small changes of signal intensity, often on the order of several percent, quantitative NOE measurements can be challenging. Hype... |
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A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia.
Int. J. Mol. Sci. 16 , 13043-64, (2015) A randomized prospective clinical study performed on a group of 74 pregnant women (43 presenting with severe preeclampsia) proved that urinary levels of 15-F(2t)-isoprostane were significantly higher in preeclamptic patients relative to the control (3.05 vs. ... |
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Proton beam radiation induces DNA damage and cell apoptosis in glioma stem cells through reactive oxygen species.
Sci. Rep. 5 , 13961, (2015) Glioblastoma multiforme (GBM) is among the most lethal of human malignancies. Most GBM tumors are refractory to cytotoxic therapies. Glioma stem cells (GSCs) significantly contribute to GBM progression and post-treatment tumor relapse, therefore serving as a ... |
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Formation of stable radicals in catechin/nitrous acid systems: participation of dinitrosocatechin.
Food Chem. 194 , 1116-22, (2015) Catechins are transformed into dinitrosocatechins (diNOcats) and then oxidized to the quinones by salivary nitrite under conditions simulating the stomach. This manuscript deals with formation of stable radicals in the NO group of diNOcat during nitrite-induc... |
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Electrochemical electron paramagnetic resonance utilizing loop gap resonators and micro-electrochemical cells.
Phys. Chem. Chem. Phys. 17 , 23438-47, (2015) A miniaturised electrochemical cell design for Electron Paramagnetic Resonance (EPR) studies is reported. The cell incorporates a Loop Gap Resonator (LGR) for EPR investigation of electrochemically generated radicals in aqueous (and other large dielectric los... |
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SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex.
J. Biol. Inorg. Chem. 20 , 1287-98, (2015) The search for novel anticancer therapeutic agents is an urgent and important issue in medicinal chemistry. Here, we report on the biological activity of the copper-based bioinorganic complex Cu4 (2,4-di-tert-butyl-6-(1H-imidazo- [1, 10] phenanthrolin-2-yl)ph... |