1-(4-Fluorophenyl)piperazine

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Names

[ CAS No. ]:
2252-63-3

[ Name ]:
1-(4-Fluorophenyl)piperazine

[Synonym ]:
Flipiperazine
1-(4-fluoro-phenyl)piperazine
4-(4-fluorophenyl)-piperazine
1-(p-Fluorophenyl)piperazine
N-(4-Fluorophenyl)piperazine
4-fluorophenylpiperazine
p-Fluorophenylpiperazine
para-fluorophenylpiperazine
EINECS 218-846-6
MFCD00005960

Chemical & Physical Properties

[ Density]:
1.0

[ Boiling Point ]:
118-123 °C0.1 mm Hg(lit.)

[ Melting Point ]:
30-33 °C(lit.)

[ Molecular Formula ]:
C10H13FN2

[ Molecular Weight ]:
180.22200

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
180.10600

[ PSA ]:
15.27000

[ LogP ]:
1.62910

[ Vapour Pressure ]:
1.78E-05mmHg at 25°C

[ Index of Refraction ]:
1.5585-1.5605

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
2811

[ WGK Germany ]:
2

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Bis(2-Chloroethyl)amine hydrochloride
  • 4-Fluoroaniline
  • 1-Bromo-4-fluorobenzene
  • Piperazine
  • Tri-o-tolylphosphine
  • 1-(4-fluorophenyl)-4-(p-tolylsulphonyl)piperazine
  • N-Boc-piperazine
  • ETHYL BIS(2-BROMOETHYL)CARBAMATE

DownStream

  • 3-[4-(4-fluorophenyl)piperazin-1-yl]propan-1-ol
  • 2-[4-(4-fluorophenyl)piperazin-1-yl]ethanamine
  • Fananserin
  • 2-CHLORO-1-[4-(4-FLUORO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE
  • 2-Buten-1-one, 3-(4-(4-fluorophenyl)-1-piperazinyl)-1-phenyl-
  • (Z)-1-(3-fluorophenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]but-2-en-1-one
  • 1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]-2-methyl-prop-2-en-1-one
  • 2-BENZOXAZOLINONE, 6-(2-(4-(p-FLUOROPHENYL)-1-PIPERAZINYL)PROPIONYL)-3-METHYL-
  • 1-(3,4-Dihydro-2H-1-benzopyran-3-yl)-4-(4-fluorophenyl)piperazine
  • 2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl 3-oxobutanoate

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder.

J. Psychiatr. Res. 43(10) , 887-94, (2009)

Serotonin-1A receptors may play a role in the pathophysiology of depression and suicide. In postmortem brain tissue, agonist binding to serotonin-1A receptors is reportedly increased or unchanged in d...

The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain.

Neuropharmacology 21(2) , 163-9, (1982)

Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-...

Rapid synthesis of N, N'-disubstituted piperazines. Application to the preparation of No carrier added 1-(4-[18F] fluorophenyl) piperazine and of an [18F]-selective ligand of serotoninergic receptors (5HT2 antagonist). Collins M, et al.

J. Chem. Soc. Perkin Trans. I 23 , 3185-88, (1992)


More Articles

Related Compounds

  • 1-(4-Fluorophenyl)piperazinediium dichloride
  • 1-[(4-FLUOROPHENYL)SULFONYL]PIPERAZINE
  • 1-(4-fluorophenyl)-4-(p-tolylsulphonyl)piperazine
  • 1-(4-Fluorophenyl)-4-(4-nitrophenyl)piperazine
  • 1-(4-fluorophenyl)sulfonyl-4-(4-nitrophenyl)piperazine
  • 1-{(4-Fluorophenyl)[4-(trifluoromethyl)phenyl]methyl}piperazine ethanedioate (1:1)