1-(4-Fluorophenyl)piperazine
1-(4-Fluorophenyl)piperazine structure
|
Common Name | 1-(4-Fluorophenyl)piperazine | ||
|---|---|---|---|---|
| CAS Number | 2252-63-3 | Molecular Weight | 180.22200 | |
| Density | 1.0 | Boiling Point | 118-123 °C0.1 mm Hg(lit.) | |
| Molecular Formula | C10H13FN2 | Melting Point | 30-33 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | >230 °F | |
| Symbol |
GHS07 |
Signal Word | Warning | |
| Name | 1-(4-Fluorophenyl)piperazine |
|---|---|
| Synonym | More Synonyms |
| Density | 1.0 |
|---|---|
| Boiling Point | 118-123 °C0.1 mm Hg(lit.) |
| Melting Point | 30-33 °C(lit.) |
| Molecular Formula | C10H13FN2 |
| Molecular Weight | 180.22200 |
| Flash Point | >230 °F |
| Exact Mass | 180.10600 |
| PSA | 15.27000 |
| LogP | 1.62910 |
| Vapour Pressure | 1.78E-05mmHg at 25°C |
| Index of Refraction | 1.5585-1.5605 |
| Storage condition | Refrigerator |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | 2811 |
| WGK Germany | 2 |
| Packaging Group | III |
| Hazard Class | 8 |
| HS Code | 2933599090 |
|
~86%
1-(4-Fluorophen... CAS#:2252-63-3 |
| Literature: Liu, Kevin G.; Robichaud, Albert J. Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7921 - 7922 |
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~%
1-(4-Fluorophen... CAS#:2252-63-3 |
| Literature: Tetrahedron Letters, , vol. 39, # 7 p. 617 - 620 |
|
~%
1-(4-Fluorophen... CAS#:2252-63-3 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1375 - 1377 |
|
~%
1-(4-Fluorophen... CAS#:2252-63-3
Detail
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| Literature: Tetrahedron Letters, , vol. 39, # 7 p. 617 - 620 |
|
~%
1-(4-Fluorophen... CAS#:2252-63-3 |
| Literature: US5929281 A1, ; |
|
~67%
1-(4-Fluorophen... CAS#:2252-63-3 |
| Literature: Collins, Michael; Lasne, Marie-Claire; Barre, Louisa Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 23 p. 3185 - 3188 |
|
~%
1-(4-Fluorophen... CAS#:2252-63-3 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 24 p. 7381 - 7384 |
|
~%
1-(4-Fluorophen... CAS#:2252-63-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 23 p. 3185 - 3188 |
|
~75%
1-(4-Fluorophen... CAS#:2252-63-3 |
| Literature: Mishani, Eyal; Dence, Carmen S.; McCarthy, Timothy J.; Welch, Michael J. Tetrahedron Letters, 1996 , vol. 37, # 3 p. 319 - 322 |
| Precursor 8 | |
|---|---|
| DownStream 10 | |
![3-[4-(4-fluorophenyl)piperazin-1-yl]propan-1-ol structure](https://image.chemsrc.com/caspic/091/105173-87-3.png)
CAS#:105173-87-3![2-[4-(4-fluorophenyl)piperazin-1-yl]ethanamine structure](https://image.chemsrc.com/caspic/353/27144-84-9.png)
CAS#:27144-84-9
CAS#:127625-29-0![2-CHLORO-1-[4-(4-FLUORO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE structure](https://image.chemsrc.com/caspic/281/330601-48-4.png)
CAS#:330601-48-4
CAS#:76691-03-7![(Z)-1-(3-fluorophenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]but-2-en-1-one structure](https://image.chemsrc.com/caspic/039/76691-08-2.png)
CAS#:76691-08-2![1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]-2-methyl-prop-2-en-1-one structure](https://image.chemsrc.com/caspic/294/76691-19-5.png)
CAS#:76691-19-5
CAS#:82211-65-2
CAS#:83823-55-6![2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl 3-oxobutanoate structure](https://image.chemsrc.com/caspic/348/90096-18-7.png)
CAS#:90096-18-7| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder.
J. Psychiatr. Res. 43(10) , 887-94, (2009) Serotonin-1A receptors may play a role in the pathophysiology of depression and suicide. In postmortem brain tissue, agonist binding to serotonin-1A receptors is reportedly increased or unchanged in d... |
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The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain.
Neuropharmacology 21(2) , 163-9, (1982) Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-... |
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Rapid synthesis of N, N'-disubstituted piperazines. Application to the preparation of No carrier added 1-(4-[18F] fluorophenyl) piperazine and of an [18F]-selective ligand of serotoninergic receptors (5HT2 antagonist). Collins M, et al.
J. Chem. Soc. Perkin Trans. I 23 , 3185-88, (1992)
|
| Flipiperazine |
| 1-(4-fluoro-phenyl)piperazine |
| 4-(4-fluorophenyl)-piperazine |
| 1-(p-Fluorophenyl)piperazine |
| N-(4-Fluorophenyl)piperazine |
| 4-fluorophenylpiperazine |
| p-Fluorophenylpiperazine |
| para-fluorophenylpiperazine |
| EINECS 218-846-6 |
| MFCD00005960 |
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- Purity: 98.0%
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