Clodronate Disodium

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Names

[ Name ]:
Clodronate Disodium

[Synonym ]:
Clastoban
Clodronic acid disodium salt
Cl2MDP Clodronate disodium Clodronic acid disodium salt DMDP
Bonefos
UNII-Y05R4GCQ1H
(Dichloromethylene)diphosphonic acid,disodium salt
Phosphonic acid, (dichloromethylene)bis-, sodium salt (1:2)
EINECS 245-078-9
MFCD01632786
Clasteon
Lytos
Ossiten
Sodium clodronate
disodium,[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
Loron
Disodium Clodronate
Mebonat
Clodronate Disodium
Clodronic Acid, Disodium Salt, Hydrate
disodium (dichloromethanediyl)bis[hydrogen (phosphonate)]
Disodium (dichloromethylene)bis[hydrogen (phosphonate)]
Ostac
Dichloromethylenediphosphonic acid disodium salt

Chemical & Physical Properties

[ Density]:
2.306g/cm3

[ Boiling Point ]:
474.7ºC at 760mmHg

[ Melting Point ]:
>330ºC

[ Molecular Formula ]:
CH₂Cl₂Na₂O₆P₂

[ Molecular Weight ]:
288.856

[ Flash Point ]:
240.9ºC

[ Exact Mass ]:
287.849915

[ PSA ]:
140.34000

[ LogP ]:
1.30710

[ Vapour Pressure ]:
2.55E-10mmHg at 25°C

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ7640700

CHEMICAL NAME :: Phosphonic acid, (dichloromethylene)bis-, disodium salt

CAS REGISTRY NUMBER :: 22560-50-5

LAST UPDATED :: 199512

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C-H2-Cl2-O6-P2.2Na

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/kg/15D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg/3D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 182 gm/kg/26W-I

TOXIC EFFECTS :: Musculoskeletal - changes in teeth and supporting structures Musculoskeletal - other changes Related to Chronic Data - death

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 59,129,1986

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
SZ7640700

[ HS Code ]:
2931900090

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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