Clodronate Disodium
Suppliers
Names
[ CAS No. ]:
22560-50-5
[ Name ]:
Clodronate Disodium
[Synonym ]:
Clastoban
Clodronic acid disodium salt
Cl2MDP Clodronate disodium Clodronic acid disodium salt DMDP
Bonefos
UNII-Y05R4GCQ1H
(Dichloromethylene)diphosphonic acid,disodium salt
Phosphonic acid, (dichloromethylene)bis-, sodium salt (1:2)
EINECS 245-078-9
MFCD01632786
Clasteon
Lytos
Ossiten
Sodium clodronate
disodium,[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
Loron
Disodium Clodronate
Mebonat
Clodronate Disodium
Clodronic Acid, Disodium Salt, Hydrate
disodium (dichloromethanediyl)bis[hydrogen (phosphonate)]
Disodium (dichloromethylene)bis[hydrogen (phosphonate)]
Ostac
Dichloromethylenediphosphonic acid disodium salt
Chemical & Physical Properties
[ Density]:
2.306g/cm3
[ Boiling Point ]:
474.7ºC at 760mmHg
[ Melting Point ]:
>330ºC
[ Molecular Formula ]:
CH2Cl2Na2O6P2
[ Molecular Weight ]:
288.856
[ Flash Point ]:
240.9ºC
[ Exact Mass ]:
287.849915
[ PSA ]:
140.34000
[ LogP ]:
1.30710
[ Vapour Pressure ]:
2.55E-10mmHg at 25°C
[ Storage condition ]:
-20°C Freezer
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SZ7640700
- CHEMICAL NAME :
- Phosphonic acid, (dichloromethylene)bis-, disodium salt
- CAS REGISTRY NUMBER :
- 22560-50-5
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C-H2-Cl2-O6-P2.2Na
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3600 mg/kg/15D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1200 mg/kg/3D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - pig
- DOSE/DURATION :
- 182 gm/kg/26W-I
- TOXIC EFFECTS :
- Musculoskeletal - changes in teeth and supporting structures Musculoskeletal - other changes Related to Chronic Data - death
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 59,129,1986
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
SZ7640700
[ HS Code ]:
2931900090
Customs
[ HS Code ]: 2931900090
[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%
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