Clodronate Disodium

Modify Date: 2024-01-02 17:13:09

Clodronate Disodium structure	Common Name	Clodronate Disodium
	CAS Number	22560-50-5	Molecular Weight	288.856
	Density	2.306g/cm3	Boiling Point	474.7ºC at 760mmHg
	Molecular Formula	CH₂Cl₂Na₂O₆P₂	Melting Point	>330ºC
	MSDS	USA	Flash Point	240.9ºC

Use of Clodronate Disodium

Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget’s disease and osteolytic bone metastases[1][2][3].

Name	clodronic acid disodium salt
Synonym	More Synonyms

Description	Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget’s disease and osteolytic bone metastases[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Clodronic acid (Clodronate) disodium salt induces rapid apoptosis in osteoclasts by preventing translocation of ADP into mitochondria after being internalised via resorption. Consequently, ATP production is inhibited, leading to induction of apoptosis by means of release of cytochrome C into the cytoplasm[2].
In Vivo	Clodronic acid (Clodronate) disodium salt (6.25-25 mg/kg; p.o.; daily for 28 days) slightly decreases the hindpaw swelling at doses of 12.5 and 25 mg/kg[3]. Animal Model: Male Lewis rats, aged 7 weeks[3] Dosage: 6.25, 12.5, and 25 mg/kg Administration: P.o.; daily for 28 days Result: Hindpaw swelling was significantly smaller than in adjuvant-arthritis (AA)-control at 25 mg/kg on days 21 and 28 (87 and 88% of AA-control, respectively) and at 12.5 mg/kg on day 28.
References	[1]. Mönkkönen J, et al. Clodronate (dichloromethylene bisphosphonate) inhibits LPS-stimulated IL-6 and TNF production by RAW 264 cells. Life Sci. 1994;54(14):PL229‐PL234. [2]. Tanakol R, et al. Clodronic acid in the treatment of postmenopausal osteoporosis. Clin Drug Investig. 2007;27(6):419‐433. [3]. Itoh F, et al. Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis. Inflammation. 2004;28(1):15‐21.

Density	2.306g/cm3
Boiling Point	474.7ºC at 760mmHg
Melting Point	>330ºC
Molecular Formula	CH₂Cl₂Na₂O₆P₂
Molecular Weight	288.856
Flash Point	240.9ºC
Exact Mass	287.849915
PSA	140.34000
LogP	1.30710
Vapour Pressure	2.55E-10mmHg at 25°C
Storage condition	-20°C Freezer

Clodronate Disodium MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ7640700

CHEMICAL NAME :: Phosphonic acid, (dichloromethylene)bis-, disodium salt

CAS REGISTRY NUMBER :: 22560-50-5

LAST UPDATED :: 199512

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C-H2-Cl2-O6-P2.2Na

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/kg/15D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg/3D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 182 gm/kg/26W-I

TOXIC EFFECTS :: Musculoskeletal - changes in teeth and supporting structures Musculoskeletal - other changes Related to Chronic Data - death

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 59,129,1986

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SZ7640700
HS Code	2931900090

HS Code	2931900090
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Clodronate Disodium
Price: ￥248.0/250mg ￥688.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Clodronate disodium
Price: $300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sodium clodronate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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