TAK-779

Suppliers

Names

[ Name ]:
TAK-779

[Synonym ]:
N,N-Dimethyl-N-[4-({[2-(4-methylphenyl)-6,7-dihydro-5H-benzo[7]annulen-8-yl]carbonyl}amino)benzyl]tetrahydro-2H-pyran-4-aminium chloride
2H-Pyran-4-aminium, N-[[4-[[[6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-, chloride (1:1)
TAK-779

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₃₉ClN₂O₂

[ Molecular Weight ]:
531.128

[ Exact Mass ]:
530.270020

[ PSA ]:
26.30000

[ LogP ]:
8.17110

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model.

Transpl. Immunol. 25(1) , 49-55, (2011)

The effects of FK506, and TAK-779, antagonists of CCR5 and CXCR3, were investigated using a rat intestinal transplantation model. Small intestines from DA rats were heterotopically transplanted into L...

Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate.

J. Acquir. Immune Defic. Syndr. 55(4) , 420-7, (2010)

We previously reported vicriviroc (VCV) resistance in an HIV-infected subject and used deep sequencing and clonal analyses to track the evolution of V3 sequence forms over 28 weeks of therapy. Here, w...

Synthesis of [19, 35, 36-(13)C(3)]-labeled TAK779 as a molecular probe.

Bioorg. Med. Chem. 17(16) , 5769-74, (2009)

N,N-Dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium chloride (TAK779) is a potent and selective non-peptide CCR5 antagonist...

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