4-Aminopyrazolo[3,4-d]pyrimidine
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Names
[ CAS No. ]:
2380-63-4
[ Name ]:
4-Aminopyrazolo[3,4-d]pyrimidine
[Synonym ]:
Methyl 3-piperidinylacetate hydrochloride (1:1)
7-deaza-8-aza-adenine
8-aza-7-deazaadenine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine
1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
EINECS 219-174-6
pyrazolo[3,4-d]pyrimidin-4-amine
Pyrazoloadenine
Aminopurinol
4-aminopyrazolo-(3,4-d)pyrimidine
4-aminopyrazolo[5,4-d]pyrimidine
4-Aminopyrazolopyrimidine
1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine 4-Amino-1H-pyrazolo[3,4-d]pyrimidine
Pyrazolo[3,4-d]pyrimidin-4-amin
4-app
ADENINE ANTIMETABOLITE
MFCD00005688
3-Piperidineacetic acid, methyl ester, hydrochloride (1:1)
4-AMINOPYRAZOLO{3,4-D}PYRIMIDINE
1(H)-4-amine-pyrazolo[3,4-d]pyrimidine
4-Amino pyrazolo[3,4-d]pyrimidine
Chemical & Physical Properties
[ Density]:
1.612g/cm3
[ Boiling Point ]:
431.1ºC at 760mmHg
[ Melting Point ]:
>325 °C(lit.)
[ Molecular Formula ]:
C5H5N5
[ Molecular Weight ]:
193.671
[ Flash Point ]:
244.4ºC
[ Exact Mass ]:
193.086960
[ PSA ]:
80.48000
[ LogP ]:
0.51630
[ Storage condition ]:
-20°C Freezer
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UR0717000
- CHEMICAL NAME :
- 1H-Pyrazolo(3,4-d)pyrimidine, 4-amino-
- CAS REGISTRY NUMBER :
- 2380-63-4
- BEILSTEIN REFERENCE NO. :
- 0005824
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C5-H5-N5
- MOLECULAR WEIGHT :
- 135.15
- WISWESSER LINE NOTATION :
- T56 BMN GN INJ FZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 141 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 228 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 181 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD10 - Lethal Dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Liver - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - urine volume increased
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 22500 mg/kg/9D-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Blood - changes in bone marrow (not otherwise specified) Blood - changes in platelet count
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 5 umol/L
- REFERENCE :
- ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 48,319,1967
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H315-H319-H335
[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R23/24/25;R36/37/38
[ Safety Phrases ]:
S26-S36/37/39-S45-S22
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
UR0717000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2933990090
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Neurosci. 35(11) , 4540-51, (2015)
The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in t...
J. Clin. Invest. 124(6) , 2585-98, (2014)
Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress-associated transcri...
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 226-41, (2012)
The FTIR and FT-Raman spectra of 2-aminopyrimidine (2-AP) and 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) has been recorded in the region 4000-400 and 3500-100 cm(-1), respectively. The tautomeric stabil...