4-Aminopyrazolo[3,4-d]pyrimidine
![4-Aminopyrazolo[3,4-d]pyrimidine Structure](https://image.chemsrc.com/caspic/384/2380-63-4.png)
4-Aminopyrazolo[3,4-d]pyrimidine structure
|
Common Name | 4-Aminopyrazolo[3,4-d]pyrimidine | ||
|---|---|---|---|---|
| CAS Number | 2380-63-4 | Molecular Weight | 193.671 | |
| Density | 1.612g/cm3 | Boiling Point | 431.1ºC at 760mmHg | |
| Molecular Formula | C5H5N5 | Melting Point | >325 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 244.4ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
|
Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.
J. Neurosci. 35(11) , 4540-51, (2015) The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in the DCN may underlie central tinnitus. The neurotransmitter ... |
|
|
Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
J. Clin. Invest. 124(6) , 2585-98, (2014) Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress-associated transcription factor XBP-1 in B cells and found that XBP-1 deficien... |
|
|
Spectroscopic, electronic structure and natural bond analysis of 2-aminopyrimidine and 4-aminopyrazolo[3,4-d]pyrimidine: a comparative study.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 226-41, (2012) The FTIR and FT-Raman spectra of 2-aminopyrimidine (2-AP) and 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) has been recorded in the region 4000-400 and 3500-100 cm(-1), respectively. The tautomeric stability, optimized geometry, frequency and intensity of the vib... |
|
|
Cholesterogenesis: derepression in extrahepatic tissues with 4-aminopyrazolo (3,4-d) pyrimidine.
Science 193 , 903, (1976) Administration of 4-aminopyrazolo [3,4-d] pyrimidine decreased serum cholesterol levels in the rat to less than 5 milligrams per deciliter. Coincident with this change, there was a 2.1 - to 16.0-fold increase in the rate of sterol synthesis in seven extrahepa... |
|
|
Gonadotropin modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in desensitized luteinized rat ovary.
Biochemistry 23 , 4533, (1984) These studies were done to examine the effect of gonadotropin on rat luteal 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity (the rate-limiting step in cholesterol biosynthesis) in ovaries of pregnant mare's serum gonadotropin (PMSG)-human c... |
|
|
mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
PLoS ONE 9(9) , e106316, (2014) Stimulation of type I metabotropic glutamate receptors (mGluR1/5) in several neuronal types induces slow excitatory responses through activation of transient receptor potential canonical (TRPC) channels. GABAergic cerebellar molecular layer interneurons (MLIs... |
|
|
[Riboflavin overproduction in 4-aminopyrazole[3,4-d]pyrimidine-treated yeast Pichia guilliermondii].
Prikl. Biokhim. Mikrobiol. 38(3) , 268-72, (2002) More than 90 mutants resistant to the adenine analogue 4-aminopyrazole[3,4-d]pyrimidine (4-APP), were isolated from a wild-type strain of yeast Pichia guilliermondii. Some of Appr mutants accumulated noticeable amounts of products absorbing at 260 nm in the c... |
|
|
Role for circulating lipoproteins in protection from endotoxin toxicity.
Infect. Immun. 63(5) , 2041-6, (1995) Previous studies have shown that endotoxin (lipopolysaccharide [LPS])-induced death can be prevented by preincubating LPS with lipoproteins in vitro or by infusing large quantities of lipids into animals prior to LPS administration. In the present study we de... |
|
|
Ovarian vitamin E accumulation: evidence for a role of lipoproteins.
Endocrinology 135(2) , 533-9, (1994) Reactive oxygen species, such as superoxide, hydrogen peroxide, and lipid peroxides, impair luteal function. Vitamin E, a lipophilic antioxidant vitamin, provides a major avenue of protection by scavenging free radicals and terminating lipid peroxidation. We ... |
|
|
Regulation of lipoprotein lipase activity in cardiac myocytes from control and diabetic rat hearts by plasma lipids.
Can. J. Physiol. Pharmacol. 70(9) , 1271-9, (1992) The objective of this investigation was to test the hypothesis that the diabetes-induced reduction in lipoprotein lipase activity in cardiac myocytes may be due to hypertriglyceridemia. Administration of 4-aminopyrazolopyrimidine (50 mg/kg) to control rats fo... |