2-(6-Methoxynaphthalen-2-yl)acetic acid

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Names

[ CAS No. ]:
23981-47-7

[ Name ]:
2-(6-Methoxynaphthalen-2-yl)acetic acid

[Synonym ]:
(6-Methoxy-2-naphthyl)acetic acid
(6-methoxynaphthalen-2-yl)acetic acid
2-Naphthaleneacetic acid, 6-methoxy-
6-Methoxy-2-naphthaleneacetic Acid
2-(6-methoxynaphthalen-2-yl)acetic acid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
408.8±20.0 °C at 760 mmHg

[ Melting Point ]:
171-173ºC

[ Molecular Formula ]:
C13H12O3

[ Molecular Weight ]:
216.233

[ Flash Point ]:
160.7±15.3 °C

[ Exact Mass ]:
216.078644

[ PSA ]:
46.53000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.625

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ1045000
CHEMICAL NAME :
2-Naphthaleneacetic acid, 6-methoxy-
CAS REGISTRY NUMBER :
23981-47-7
BEILSTEIN REFERENCE NO. :
2371586
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H12-O3
MOLECULAR WEIGHT :
216.25
WISWESSER LINE NOTATION :
L66J CO1 H1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 119,600,1980

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-[2-(6-methoxy-2-naphthyl)-1-thioxoethyl]morpholine
  • 2--(6--methoxynaphthalen--2--yl)acetaldehyde
  • 2-(6-methoxynaphthalen-2-yl)acetonitrile
  • methyl 2-(6-methoxynaphthalen-2-yl)acetate
  • propyl 6-methoxy-2-naphthylacetate
  • (6-methoxynaphthalen-2-yl)acetic acid ethyl ester
  • isobutyl 6- methoxy-2-naphthylacetate
  • n-butyl 6-methoxy-2-naphthylacetate
  • 2-Acetyl-6-methoxynaphthalene
  • 6-Methoxy-2-naphthaldehyde

DownStream

  • O-Desmethylnaproxen
  • 2-(6-Methoxynaphthalen-2-yl)propanoic acid
  • 6-Methoxy-2-naphthaldehyde
  • 6-Methoxy-2-naphthalenemethanol
  • methyl 2-(6-methoxynaphthalen-2-yl)acetate
  • (S)-Naproxen Methyl Ester
  • Naproxen

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 6-methoxy-α-methylnaphthalene-2-acetic acid, compound with ethylamine (1:1)
  • methyl 2-(6-methoxynaphthalen-2-yl)acetate
  • (S)-6-methoxy-α-methylnaphthalene-2-acetic acid, compound with 2-aminobutan-1-ol (1:1)
  • 2-(6-Methoxynaphthalen-2-yl)propanoic acid
  • 2-(6-Methoxynaphthalen-2-yl)-isonicotinic acid
  • 2-(6-acetylnaphthalen-2-yl)acetic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • benzyl N-{2-[4-(morpholin-4-yl)phenyl]-2-oxoethyl}carbamate