1,2,7,8-Diepoxyoctane
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Names
[ CAS No. ]:
2426-07-5
[ Name ]:
1,2,7,8-Diepoxyoctane
[Synonym ]:
octane-1,2,7,8-diepoxide
1,7-Octadiene Diepoxide
Octane,1,2:7,8-diepoxy
Oxirane, 2,2'-(1,4-butanediyl)bis-
2,2'-Butane-1,4-diyldioxirane
EINECS 219-375-9
MFCD00005155
2,2'-(1,4-Butanediyl)dioxirane
UNII:4IJ1M5W7LL
1,2-Epoxy-7,8-epoxyoctane
2-[4-(oxiran-2-yl)butyl]oxirane
Octa-1,7-diene diepoxide
1,2,7,8-Octadiene bisepoxide
Chemical & Physical Properties
[ Density]:
0.997
[ Boiling Point ]:
240.0±0.0 °C at 760 mmHg
[ Molecular Formula ]:
C8H14O2
[ Molecular Weight ]:
142.196
[ Flash Point ]:
98 ºC
[ Exact Mass ]:
142.099380
[ PSA ]:
25.06000
[ LogP ]:
0.86
[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.445
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RG9450000
- CAS REGISTRY NUMBER :
- 2426-07-5
- BEILSTEIN REFERENCE NO. :
- 0104873
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C8-H14-O2
- MOLECULAR WEIGHT :
- 142.22
- WISWESSER LINE NOTATION :
- T3OTJ B4- BT3OTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1070 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 320 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6600 mg/kg/55W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- Specific locus test
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 12500 nmol/L
- REFERENCE :
- JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),587,1979
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H311-H341-H350
[ Precautionary Statements ]:
P201-P280-P308 + P313
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R22;R24;R40
[ Safety Phrases ]:
S36/37/39-S45
[ RIDADR ]:
UN 2810 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
RG9450000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2910900090
Synthetic Route
Customs
[ HS Code ]: 2910900090
[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
Articles
Genet. Mol. Res. 1(1) , 79-89, (2002)
The sensitivity responses of seven pso mutants of Saccharomyces cerevisiae towards the mutagens N-nitrosodiethylamine (NDEA), 1,2:7,8-diepoxyoctane (DEO), and 8-hydroxyquinoline (8HQ) further substant...
Mutat. Res. 441(1) , 85-93, (1999)
The time-dependent dose-response relationships for the induction of DNA double-strand breaks (DSB) assessed by pulsed-field gel electrophoresis (PFGE) and for viability (evaluated by the MTT cytotoxic...
Chem. Res. Toxicol. 9(6) , 994-1000, (1996)
The carcinogenicity of epoxide compounds has been attributed to covalent binding to DNA. Whereas monoepoxides form only monoadducts, diepoxides can form both monoadducts and interstrand cross-links. T...