1,2,7,8-Diepoxyoctane
1,2,7,8-Diepoxyoctane structure
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Common Name | 1,2,7,8-Diepoxyoctane | ||
|---|---|---|---|---|
| CAS Number | 2426-07-5 | Molecular Weight | 142.196 | |
| Density | 0.997 | Boiling Point | 240.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C8H14O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 98 ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress.
Genet. Mol. Res. 1(1) , 79-89, (2002) The sensitivity responses of seven pso mutants of Saccharomyces cerevisiae towards the mutagens N-nitrosodiethylamine (NDEA), 1,2:7,8-diepoxyoctane (DEO), and 8-hydroxyquinoline (8HQ) further substantiated their allocation into two distinct groups: genes PSO1... |
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Discrimination between genotoxicity and cytotoxicity for the induction of DNA double-strand breaks in cells treated with aldehydes and diepoxides.
Mutat. Res. 441(1) , 85-93, (1999) The time-dependent dose-response relationships for the induction of DNA double-strand breaks (DSB) assessed by pulsed-field gel electrophoresis (PFGE) and for viability (evaluated by the MTT cytotoxicity test) were investigated in order to discriminate betwee... |
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1,2,5,6-Diepoxyhexane and 1,2,7,8-diepoxyoctane cross-link duplex DNA at 5'-GNC sequences.
Chem. Res. Toxicol. 9(6) , 994-1000, (1996) The carcinogenicity of epoxide compounds has been attributed to covalent binding to DNA. Whereas monoepoxides form only monoadducts, diepoxides can form both monoadducts and interstrand cross-links. The latter are believed to be the more significant cytotoxic... |
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Deletogenic activity of 1,2:7,8-diepoxyoctane in the Salmonella typhimurium tester strain TA102.
Mutat. Res. 437 , 165-173, (1999) 1,2:7,8-Diepoxyoctane (DEO), whose deletogenic activity was first demonstrated in ad-3 system of Neurospora crassa and then in different species, has been tested in Salmonella typhimurium tester strain TA102 (hisG428(Ochre)). It was confirmed that it is a dir... |
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Chemically synthesized non-radioactive biotinylated long-chain nucleic acid hybridization probes.
Biochem. J. 251(3) , 935-8, (1988) A new method for the chemical labelling of nucleic acid with biotin to produce non-radioactive probes has been developed. NN'-Bis-(3-aminopropyl)butane-1,4-diamine (spermine) and long-chain diamino compounds (diaminohexane, diaminodecane and diaminododecane) ... |
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Novel insertion mutation in Caenorhabditis elegans.
Mol. Cell. Biol. 5(1) , 1-6, (1985) The mutation e1662 is an allele of the Caenorhabditis elegans unc-54 gene induced with the difunctional alkylating agent 1,2,7,8-diepoxyoctane. unc-54 encodes the major myosin heavy chain isozyme of body wall muscle cells. Filter-transfer hybridization and DN... |
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Diepoxybutane and diepoxyoctane interstrand cross-linking of the 5S DNA nucleosomal core particle.
Biochemistry 40(35) , 10677-85, (2001) Diepoxyalkanes form interstrand cross-links in DNA oligomers preferentially at 5'-GNC sites. We have examined cross-linking by 1,2,3,4-diepoxybutane (DEB) and 1,2,7,8-diepoxyoctane (DEO) within a fragment of the 5S RNA gene of Xenopus borealis in both the fre... |
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Synthesis and characterization of a novel hyaluronic acid hydrogel.
J. Biomater. Sci. Polym. Ed. 17(4) , 419-33, (2006) Hyaluronic acid (hyaluronan, HA) has many medical applications as a biomaterial. To enhance its biostability, a novel hydrogel of cross-linked hyaluronic acid was prepared using a double cross-linking process, which involves building cross-linkages between hy... |