Glyphosine

Suppliers

Names

[ CAS No. ]:
2439-99-8

[ Name ]:
Glyphosine

[Synonym ]:
Glycine-N,N-bis(methylenephosphonic Acid)
N,N-di(phosphonomethyl) iminoacetic acid
N,N-bis(phosphonomethyl)aminoacetic acid
<<(carboxymethyl)imino>dimethylene>bisphosphonic acid
EINECS 219-468-4
Glyphosine [ANSI]
2-[bis(phosphonomethyl)amino]acetic acid
Glycine,N,N-bis(phosphonomethyl)
Glycine, N,N-bis(phosphonomethyl)-
N,N-bis-(phosphonomethyl)-glycine
Polaris
Glyphosphine
bis-phosphonomethyl glycine
MFCD00056670
2-(Bis(phosphonomethyl)amino)acetic acid
N,N-Bis(phosphonomethyl)glycine
nitriloacetatodimethylenephosphonic acid
N-Carboxymethyl-N,N-bis(methylenephosphonic Acid)amine
Caswell No. 471A
Glyphosine

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
668.4±65.0 °C at 760 mmHg

[ Melting Point ]:
263°C

[ Molecular Formula ]:
C4H11NO8P2

[ Molecular Weight ]:
263.080

[ Flash Point ]:
358.0±34.3 °C

[ Exact Mass ]:
262.996002

[ PSA ]:
175.22000

[ LogP ]:
-2.89

[ Vapour Pressure ]:
0.0±4.4 mmHg at 25°C

[ Index of Refraction ]:
1.594

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB9120000
CHEMICAL NAME :
Glycine, N,N-bis(phosphonomethyl)-
CAS REGISTRY NUMBER :
2439-99-8
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C4-H11-N-O8-P2
MOLECULAR WEIGHT :
263.10
WISWESSER LINE NOTATION :
QPQO&1N1VQ1PQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3925 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,60,1976/1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1920 mg/kg/24D-C
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in thymus weight Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 30,103,1984

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R41

[ Safety Phrases ]:
S26-S2

[ RIDADR ]:
UN 3261 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
MB9120000

[ Packaging Group ]:
III

[ Hazard Class ]:
8.0

[ HS Code ]:
2931900042

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Formaldehyde
  • Glycine
  • IMINO-BIS(METHYLPHOSPHONIC ACID)
  • Chloroacetic acid
  • 2-(dimethoxyphosphorylmethylamino)acetic acid
  • Sodium chloroacetate

DownStream

  • methylaminomethylphosphonic acid
  • hydrated phosphorylmethanal
  • Glyphosate
  • IMINO-BIS(METHYLPHOSPHONIC ACID)
  • [(methylimino)dimethylene]bisphosphonic acid

Customs

[ HS Code ]: 2931900042

[ Summary ]:
2931900042 2-(bis(phosphonomethyl)amino)acetic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

Articles

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

J. Immunol. 11th ed., 187 , 5921-5930, (2011)

Class II major histocompatibility molecules are the primary susceptibility locus for many autoimmune disorders, including type 1 diabetes. Human DQ8 and I-A(g7), in the NOD mouse model of spontaneous ...

Binding of phosphonate chelating agents and pyrophosphate to apotransferrin.

Biochemistry 30(28) , 6930-6, (1991)

Difference ultraviolet spectroscopy has been used to monitor the binding of a series of phosphonate ligands to human apotransferrin. The ligands consist of pyrophosphate as well as the phosphonic acid...

Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand.

J. Med. Chem. 46(23) , 4946-51, (2003)

A series of osteotropic (bone-seeking) [(bis(phosphonomethyl)amino-kappaN)acetato-kappaO(2-)]platinum(II) complexes attached to diammine, ethane-1,2-diamine, cis-R,S-cyclohexane-1,2-diamine, trans-S,S...


More Articles