4-HYDROXYWARFARIN

Names

[ CAS No. ]:
24579-14-4

[ Name ]:
4-HYDROXYWARFARIN

[Synonym ]:
4-Hydroxywarfarin
4'-Hydroxywarfarin

Chemical & Physical Properties

[ Density]:
1.384g/cm3

[ Boiling Point ]:
522ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₁₆O₅

[ Molecular Weight ]:
324.32700

[ Flash Point ]:
190.3ºC

[ Exact Mass ]:
324.10000

[ PSA ]:
87.74000

[ LogP ]:
3.31520

[ Vapour Pressure ]:
1E-11mmHg at 25°C

[ Index of Refraction ]:
1.658

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2914501900

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Chem. Res. Toxicol. 23(5) , 939-45, (2010)

Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how meta...

Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins.

Drug Metab. Lett. 6(3) , 157-64, (2012)

Coumadin (R/S-warfarin) is a highly efficacious and widely used anticoagulant; however, its highly variable metabolism remains an important contributor to uncertainties in therapeutic responses. Pharm...

Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.

Drug Metab. Lett. 4(4) , 213-9, (2010)

Effective coumadin (R/S-warfarin) therapy is complicated by inter-individual variability in metabolism. Recent studies have demonstrated that CYP3A isoforms likely contribute to patient responses and ...

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N-(2-(4-(4-chlorophenyl)thiazol-2-yl)ethyl)-4-(6-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)butanamide
N-(2-cyclopropyl-1H-benzimidazol-5-yl)benzamide
2-(3,4-dihydroisoquinolin-2(1H)-ylmethyl)-6-(2-methoxyphenyl)pyridazin-3(2H)-one
N-(2-{[3-(acetylamino)phenyl]amino}-2-oxoethyl)-4-benzylpiperazine-1-carboxamide
2-[(2-phenylmorpholin-4-yl)methyl]-2,5,6,7-tetrahydro-3H-cyclopenta[c]pyridazin-3-one
5-Bromo-2-(prop-2-yn-1-yloxy)pyrimidine

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