4-HYDROXYWARFARIN
4-HYDROXYWARFARIN structure
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Common Name | 4-HYDROXYWARFARIN | ||
|---|---|---|---|---|
| CAS Number | 24579-14-4 | Molecular Weight | 324.32700 | |
| Density | 1.384g/cm3 | Boiling Point | 522ºC at 760mmHg | |
| Molecular Formula | C19H16O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 190.3ºC | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.
Chem. Res. Toxicol. 23(5) , 939-45, (2010) Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how metabolic capacity is influenced among patients. Cytochrome P45... |
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Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins.
Drug Metab. Lett. 6(3) , 157-64, (2012) Coumadin (R/S-warfarin) is a highly efficacious and widely used anticoagulant; however, its highly variable metabolism remains an important contributor to uncertainties in therapeutic responses. Pharmacogenetic studies report conflicting findings on the clini... |
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Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.
Drug Metab. Lett. 4(4) , 213-9, (2010) Effective coumadin (R/S-warfarin) therapy is complicated by inter-individual variability in metabolism. Recent studies have demonstrated that CYP3A isoforms likely contribute to patient responses and clinical outcomes. Despite a significant focus on CYP3A4, l... |
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In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin.
Drug Metab. Dispos. 29(6) , 877-86, (2001) It has been demonstrated that the activity of cytochrome P450 (CYP)3A4 in certain cases is stimulated by quinidine (positive heterotropic cooperativity). We report herein that the 4'- and 10-hydroxylation of S- and R-warfarin are enhanced in human liver micro... |
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Microbial models of mammalian metabolism: conversion of warfarin to 4'-hydroxywarfarin using Cunninghamella bainieri.
J. Pharm. Sci. 78(3) , 183-9, (1989) Warfarin, an anticoagulant and "metabolic probe" for cytochrome P-450 isozyme multiplicity, is metabolized to 4'-hydroxywarfarin, a principle mammalian metabolite, using the fungus Cunninghamella bainieri (UI-3065). The metabolite was isolated from cell suspe... |