Leonurine

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
496.7±55.0 °C at 760 mmHg

[ Melting Point ]:
191-193ºC

[ Molecular Formula ]:
C₁₄H₂₁N₃O₅

[ Molecular Weight ]:
311.334

[ Flash Point ]:
254.2±31.5 °C

[ Exact Mass ]:
311.148132

[ PSA ]:
126.89000

[ LogP ]:
0.22

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble2mg/mL, clear (warmed)

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2925290090

Click to get detail synthetic route

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Leonurus japonicus, Leonurus cardiaca, Leonotis leonurus: a novel HPLC study on the occurrence and content of the pharmacologically active guanidino derivative leonurine.

Pharmazie 67(12) , 973-9, (2012)

Leonurine is a prominent pharmacologically active guanidine alkaloid (4-{[amino(imino)methyl]amino} butyl-4-hydroxy-3,5-dimethoxybenzoate), mainly exerting cardiovascular, hypotensive, uterotonic, and...

Simultaneous determination and pharmacokinetic study of stachydrine and leonurine in rat plasma after oral administration of Herba Leonuri extract by LC-MS/MS.

J. Pharm. Biomed. Anal. 76 , 192-9, (2013)

A simple, sensitive and specific method was developed for simultaneous determination of stachydrine and leonurine in rat plasma using diphenhydramine as an internal standard (IS). The separation was p...

Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats.

Biomed. Chromatogr. 26(4) , 518-23, (2012)

Leonurine (SCM-198), an alkaloid from Herba Leonuri, has been suggested as a novel cardiovascular agent by pharmacology studies in preclinical stage. In present study, we report a simple, rapid and se...

More Articles