Leonurine
Suppliers
Names
[ CAS No. ]:
24697-74-3
[ Name ]:
Leonurine
[Synonym ]:
Leonurine hydrochloride
Leonurine
4-Guanidinobutyl 4-hydroxy-3,5-dimethoxybenzoate
4-Guanidino-1-butanol syringate 4-Guanidinobutyl 4-hydroxy-3,5-dimethoxybenzoate SCM-198
4-Guanidino-n-butyl syringate
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
496.7±55.0 °C at 760 mmHg
[ Melting Point ]:
191-193ºC
[ Molecular Formula ]:
C14H21N3O5
[ Molecular Weight ]:
311.334
[ Flash Point ]:
254.2±31.5 °C
[ Exact Mass ]:
311.148132
[ PSA ]:
126.89000
[ LogP ]:
0.22
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.554
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: soluble2mg/mL, clear (warmed)
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36/37/38
[ Safety Phrases ]:
26-24/25
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2925290090
Synthetic Route
Customs
[ HS Code ]: 2925290090
[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles
Pharmazie 67(12) , 973-9, (2012)
Leonurine is a prominent pharmacologically active guanidine alkaloid (4-{[amino(imino)methyl]amino} butyl-4-hydroxy-3,5-dimethoxybenzoate), mainly exerting cardiovascular, hypotensive, uterotonic, and...
J. Pharm. Biomed. Anal. 76 , 192-9, (2013)
A simple, sensitive and specific method was developed for simultaneous determination of stachydrine and leonurine in rat plasma using diphenhydramine as an internal standard (IS). The separation was p...
Biomed. Chromatogr. 26(4) , 518-23, (2012)
Leonurine (SCM-198), an alkaloid from Herba Leonuri, has been suggested as a novel cardiovascular agent by pharmacology studies in preclinical stage. In present study, we report a simple, rapid and se...