M344

Suppliers

Names

[ CAS No. ]:
251456-60-7

[ Name ]:
M344

[Synonym ]:
4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
4-(Dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide
Benzamide, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-
MFCD03453554
M 344
M344

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Melting Point ]:
161℃

[ Molecular Formula ]:
C16H25N3O3

[ Molecular Weight ]:
307.388

[ Exact Mass ]:
307.189606

[ PSA ]:
81.67000

[ LogP ]:
1.06

[ Appearance of Characters ]:
white to beige

[ Index of Refraction ]:
1.558

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble10mg/mL, clear

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-benzyloxy-7-(4-dimethylaminobenzoyl)aminoheptanamide
  • 4-(Dimethylamino)benzoic acid
  • Methyl 7-aminoheptanoate hydrochloride
  • methyl 7-(4-dimethylaminobenzoyl)aminoheptanoate
  • 7-(4-(dimethylamino)benzamido)heptanoic acid

DownStream

Articles

Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.

Hum. Mol. Genet. 23(11) , 2888-900, (2014)

Cornelia de Lange syndrome (CdLS) is a multisystem genetic disorder with distinct facies, growth failure, intellectual disability, distal limb anomalies, gastrointestinal and neurological disease. Mut...

Acetylation regulates the stability of glutamate carboxypeptidase II protein in human astrocytes.

Biochem. Biophys. Res. Commun. 450(1) , 372-7, (2014)

Glutamate carboxypeptidase II (GCPII) is known to be implicated in brain diseases such as schizophrenia and bipolar disorder, and dramatically increases in prostate cancer. Here, we investigated the r...

HDAC inhibitors target HDAC5, upregulate microRNA-125a-5p, and induce apoptosis in breast cancer cells.

Mol. Ther. 23(4) , 656-66, (2015)

Histone deacetylase inhibitors (HDACi) are novel clinical anticancer drugs that inhibit HDAC gene expression and induce cell apoptosis in human cancers. Nevertheless, the detailed mechanism or the dow...


More Articles

Related Compounds

  • M344
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,1-difluoropropan-2-amine
  • 4-(1-ethylcyclobutyl)-1H-pyrazole
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 2-[1-(2,2-difluoro-3-hydroxypropyl)-5-(1-methoxyethyl)-1H-1,2,3-triazol-4-yl]acetonitrile
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde