felbamate
Suppliers
Names
[ CAS No. ]:
25451-15-4
[ Name ]:
felbamate
[Synonym ]:
Felbatol
3-propanediol dicarbamate
EINECS 247-001-4
Felbamatum
Felbamato
1,3-Propanediol,2-phenyl-,dicarbamate
1,3-bis-carbamoyloxy-2-phenyl-propane
1,3-Bis-carbamoyloxy-2-phenyl-propan
MFCD00865296
2-Phenyl-1,3-propanediyl dicarbamate
felbamate
Felbamyl
(3-carbamoyloxy-2-phenylpropyl) carbamate
Carbamic acid,2-phenyltrimethylene ester
1,3-Propanediol, 2-phenyl-, dicarbamate
Taloxa
2-Phenylpropane-1,3-diyl dicarbamate
2-phenyl-1,3-propanediol dicarbamate
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
511.9±50.0 °C at 760 mmHg
[ Melting Point ]:
148-1500C
[ Molecular Formula ]:
C11H14N2O4
[ Molecular Weight ]:
238.240
[ Flash Point ]:
288.4±26.4 °C
[ Exact Mass ]:
238.095352
[ PSA ]:
104.64000
[ LogP ]:
1.20
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.559
[ Storage condition ]:
Store at RT
[ Water Solubility ]:
alcohol: soluble
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TZ1070000
- CHEMICAL NAME :
- 1,3-Propanediol, 2-phenyl-, dicarbamate
- CAS REGISTRY NUMBER :
- 25451-15-4
- BEILSTEIN REFERENCE NO. :
- 3345236
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C11-H14-N2-O4
- MOLECULAR WEIGHT :
- 238.27
- WISWESSER LINE NOTATION :
- ZVO1YR&1OVZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep
- REFERENCE :
- PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1985- Volume(issue)/page/year: 11,369,1995
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1296 mg/kg/18D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Gastrointestinal - other changes Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- PHPYDQ Pharmacotherapy (Carlisle, MA). (Pharmacotherapy Pub., Inc., 112 School St., Carlisle, MA 01741) V.1- 1981- Volume(issue)/page/year: 15,260,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,931,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,931,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,462,1969
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311 + H331-H370
[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol
[ WGK Germany ]:
2
[ RTECS ]:
TZ1070000
[ HS Code ]:
2924299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Ann. Neurol. 76(6) , 911-5, (2014)
Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic γ-amin...
Pharmacol. Rep. 59(4) , 462-6, (2007)
The efficacy of lamotrigine and felbamate against maximal electroshock (MES)-induced seizures was assessed under conditions mimicking the pharmacoresistance associated with an increased excitatory neu...
Discov. Med. 9(45) , 138-44, (2010)
Anti-epileptic drugs (AEDs) have a variety of mechanisms of action which are reflected through different anticonvulsant activities and behavioral effects. Two categories of AEDs are considered based o...