Monastrol

Suppliers

Names

[ CAS No. ]:
254753-54-3

[ Name ]:
Monastrol

[Synonym ]:
F3284-6466
MFCD00813077
monastrol

Chemical & Physical Properties

[ Density]:
1.34g/cm3

[ Boiling Point ]:
441.3ºC at 760mmHg

[ Melting Point ]:
185-185.9ºC(lit.)

[ Molecular Formula ]:
C₁₄H₁₆N₂O₃S

[ Molecular Weight ]:
292.35

[ Flash Point ]:
220.7ºC

[ Exact Mass ]:
292.08800

[ PSA ]:
109.72000

[ LogP ]:
1.92380

[ Vapour Pressure ]:
2.13E-08mmHg at 25°C

[ Index of Refraction ]:
1.648

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 100 mg/mL

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice.

J. Biol. Chem. 290 , 12984-98, (2015)

Tetraploidy, a state in which cells have doubled chromosomal sets, is observed in ∼20% of solid tumors and is considered to frequently precede aneuploidy in carcinogenesis. Tetraploidy is also detecte...

Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms.

J. Thorac. Cardiovasc. Surg. 286 , 6201-10, (2011)

The human Eg5 (HsEg5) protein is unique in its sensitivity to allosteric agents even among phylogenetic kin. For example, S-trityl-l-cysteine (STC) and monastrol are HsEg5 inhibitors that bind to a su...

A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly.

Sci. Rep. 5 , 10564, (2015)

How multiple spindle assembly pathways are integrated to drive bipolar spindle assembly is poorly understood. We performed an image-based double RNAi screen to identify genes encoding Microtubule-Asso...

Monastrol
oxo-monastrol
(4r)-monastrol
(4R)-MONASTROL
2,3,5,6-tetramethyl-N-(1-propionyl-1,2,3,4-tetrahydroquinolin-6-yl)benzenesulfonamide
N-(1-propionyl-1,2,3,4-tetrahydroquinolin-6-yl)-4-propylbenzenesulfonamide
2,4,6-trimethyl-N-(1-propionyl-1,2,3,4-tetrahydroquinolin-6-yl)benzenesulfonamide
3-chloro-4-fluoro-N-(1-propionyl-1,2,3,4-tetrahydroquinolin-6-yl)benzenesulfonamide
N-(1-propionyl-1,2,3,4-tetrahydroquinolin-6-yl)benzenesulfonamide
4-bromo-N-(1-propionyl-1,2,3,4-tetrahydroquinolin-6-yl)benzenesulfonamide
N-(4-bromo-2-fluorophenyl)-4-(1,1-dioxido-1,2-thiazinan-2-yl)benzamide
N-(4-bromo-2-methylphenyl)-4-(1,1-dioxido-1,2-thiazinan-2-yl)benzamide
N-(4-bromo-3-methylphenyl)-4-(1,1-dioxido-1,2-thiazinan-2-yl)benzamide
Butyl 4-(4-(1,1-dioxido-1,2-thiazinan-2-yl)benzamido)benzoate

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