Monastrol
Monastrol structure
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Common Name | Monastrol | ||
|---|---|---|---|---|
| CAS Number | 254753-54-3 | Molecular Weight | 292.35 | |
| Density | 1.34g/cm3 | Boiling Point | 441.3ºC at 760mmHg | |
| Molecular Formula | C14H16N2O3S | Melting Point | 185-185.9ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 220.7ºC | |
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Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice.
J. Biol. Chem. 290 , 12984-98, (2015) Tetraploidy, a state in which cells have doubled chromosomal sets, is observed in ∼20% of solid tumors and is considered to frequently precede aneuploidy in carcinogenesis. Tetraploidy is also detected during terminal differentiation and represents a hallmark... |
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Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms.
J. Thorac. Cardiovasc. Surg. 286 , 6201-10, (2011) The human Eg5 (HsEg5) protein is unique in its sensitivity to allosteric agents even among phylogenetic kin. For example, S-trityl-l-cysteine (STC) and monastrol are HsEg5 inhibitors that bind to a surface pocket created by the L5 loop, but neither compound i... |
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A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly.
Sci. Rep. 5 , 10564, (2015) How multiple spindle assembly pathways are integrated to drive bipolar spindle assembly is poorly understood. We performed an image-based double RNAi screen to identify genes encoding Microtubule-Associated Proteins (MAPs) that interact with the highly conser... |
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Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect.
Proc. Natl. Acad. Sci. U. S. A. 108 , 4997-5002, (2011) Despite the success of protein farnesyltransferase inhibitors (FTIs) in the treatment of certain malignancies, their mode of action is incompletely understood. Dissecting the molecular pathways affected by FTIs is important, particularly because this group of... |
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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
Science 286 , 971-914, (1999) Small molecules that perturb specific protein functions are valuable tools for dissecting complex processes in mammalian cells. A combination of two phenotype-based screens, one based on a specific posttranslational modification, the other visualizing microtu... |
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Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK.
Curr. Biol. 23(16) , 1514-26, (2013) Proper attachment of chromosomes to microtubules is crucial for the accurate segregation of chromosomes. Human chromosomes attach initially to lateral walls of microtubules. Subsequently, attachments to lateral walls disappear and attachments to microtubule e... |
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Overexpression of Eg5 causes genomic instability and tumor formation in mice.
Cancer Res. , 10138-47, (2007) Proper chromosome segregation in eukaryotes is driven by a complex superstructure called the mitotic spindle. Assembly, maintenance, and function of the spindle depend on centrosome migration, organization of microtubule arrays, and force generation by microt... |
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Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes.
FASEB J. 30 , 312-23, (2016) Proper bioriented attachment of microtubules and kinetochores is essential for the precise distribution of duplicated chromosomes to each daughter cell. An aberrant kinetochore-microtubule attachment results in chromosome instability, which leads to cellular ... |
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Targeting Aurora B to the equatorial cortex by MKlp2 is required for cytokinesis.
PLoS ONE 8 , e64826, (2013) Although Aurora B is important in cleavage furrow ingression and completion during cytokinesis, the mechanism by which kinase activity is targeted to the cleavage furrow and the molecule(s) responsible for this process have remained elusive. Here, we demonstr... |
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Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.
PLoS ONE 4 , e5282, (2009) Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-betaTrCP. Here, we show that Plk1 is also required for the time... |