Povidone Iodine
Suppliers
Names
[ CAS No. ]:
25655-41-8
[ Name ]:
Povidone Iodine
[Synonym ]:
Isobetadyne
Povidone-iodine
Disphex
Polyvinylpyrrolidone-Iodine Complex
PVP-I
Poly(vinylpyrrolidone)-Iodine complex
MFCD00084483
Povidone (iodinated)
EINECS 215-034-3
Poly(vinylpyrrolidone)–Iodine complex
Isodine
Bridine
PVP iodine
Betadine
Povidone Iodine
Chemical & Physical Properties
[ Boiling Point ]:
217.6ºC at 760 mmHg
[ Melting Point ]:
300ºC
[ Molecular Formula ]:
C6H9I2NO
[ Molecular Weight ]:
364.951
[ Flash Point ]:
93.9ºC
[ Exact Mass ]:
364.877319
[ PSA ]:
20.31000
[ LogP ]:
2.46160
[ Vapour Pressure ]:
0.132mmHg at 25°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TR1579600
- CHEMICAL NAME :
- Poly(1-(2-oxo-1-pyrrolidinyl)ethylene)iodine complex
- CAS REGISTRY NUMBER :
- 25655-41-8
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 22
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 3400 mg/kg/24H
- TOXIC EFFECTS :
- Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >8 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 640 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 480 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1450 mg/kg
- SEX/DURATION :
- female 15-22 day(s) after conception lactating female 3 week(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - physical
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 11600 mg/kg
- SEX/DURATION :
- female 15-22 day(s) after conception lactating female 3 week(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 11600 mg/kg
- SEX/DURATION :
- female 15-22 day(s) after conception lactating female 3 week(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 5000 ppm
- REFERENCE :
- APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) Volume(issue)/page/year: 19,A106,1980 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0524 No. of Facilities: 1794 (estimated) No. of Industries: 14 No. of Occupations: 15 No. of Employees: 65694 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7540 No. of Facilities: 7099 (estimated) No. of Industries: 35 No. of Occupations: 49 No. of Employees: 1075065 (estimated) No. of Female Employees: 939668 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9186 No. of Facilities: 798 (estimated) No. of Industries: 3 No. of Occupations: 16 No. of Employees: 94521 (estimated) No. of Female Employees: 86562 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
TR1579600
[ HS Code ]:
3808940010
Customs
[ HS Code ]: 3808940010
Articles
Fitoterapia 101 , 201-7, (2015)
Diplacone (1) and mimulone (2), two geranylated flavanones, have previously shown anti-inflammatory and antiradical activity in vitro. The present study aimed to evaluate their activity in vivo on a m...
J. Oral Maxillofac. Surg. 71(11) , 1833.e1-1833.e3, (2013)
Persistent oozing of blood is a common occurrence in maxillofacial surgery, and occasionally it hampers visibility and delays or even prevents continuation of the procedure. This report describes a no...
J. Oral Maxillofac. Surg. 73(1) , 18-21, (2015)
Povidone iodine is used primarily as an antiseptic to decrease surgical site infection. Its hemostatic and antiedematous properties in oral surgery also have been investigated recently.A randomized co...