DL-4-FluoroglutaMic acid

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Names

[ CAS No. ]:
2708-77-2

[ Name ]:
DL-4-FluoroglutaMic acid

[Synonym ]:
4-Fluoro-2-aminopentanedioic acid
2-Amino-4-fluoropentane-1,5-dioic acid
EINECS 220-302-8
4-Fluoro-Glutamic Acid
threo-4-fluoroglutamic acid
D,L-erythro,threo-4-fluoroglutamic acid
H-4-F-DL-Glu-OH
erythro-4-fluoroglutamic acid
DL-erythro-4-fluoroglutamic acid
DL-4-FLUOROGLUTAMIC ACID
MFCD00055778

Chemical & Physical Properties

[ Density]:
1.498 g/cm3

[ Boiling Point ]:
342.4ºC at 760 mmHg

[ Melting Point ]:
185°C (dec.)

[ Molecular Formula ]:
C5H8FNO4

[ Molecular Weight ]:
165.12000

[ Flash Point ]:
160.9ºC

[ Exact Mass ]:
165.04400

[ PSA ]:
100.62000

[ Vapour Pressure ]:
1.37E-05mmHg at 25°C

[ Index of Refraction ]:
1.491

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • triethyl 1-acetamido-3-fluoropropane-1,1,3-tricarboxylate
  • 1-acetylamino-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester
  • 2-Acetamino-2,4-dicarboxy-4-fluor-glutarsaeuretetramethylester
  • ethyl 2-acetamidoprop-2-enoate
  • Diethyl fluoromalonate

DownStream

  • L-ERYTHRO-4-FLUORO-GLUTAMIC ACID

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

4-[18F]fluoroglutamic acid (BAY 85-8050), a new amino acid radiotracer for PET imaging of tumors: synthesis and in vitro characterization.

J. Med. Chem. 54(1) , 406-10, (2011)

There is a high demand for tumor specific PET tracers in oncology imaging. Besides glucose, certain amino acids also serve as energy sources and anabolic precursors for tumors. Therefore, (18)F-labele...

Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce L-glutamic acid production.

Appl. Environ. Microbiol. 73(14) , 4491-8, (2007)

Corynebacterium glutamicum is a biotin auxotroph that secretes L-glutamic acid in response to biotin limitation; this process is employed in industrial L-glutamic acid production. Fatty acid ester sur...

Vitamin K-dependent carboxylation. Study of the hydrogen abstraction stereochemistry with gamma-fluoroglutamic acid-containing peptides.

J. Biol. Chem. 258(13) , 7897-9, (1983)

Two pentapeptides Phe-Leu-X-Glu-Val where X is either the L-threo-gamma-fluoroglutamic acid or the L-erythro-isomer have been synthesized and tested as substrates in the vitamin K-dependent carboxylat...


More Articles

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