7-Azaindole

Names

[ CAS No. ]:
271-63-6

[ Name ]:
7-Azaindole

[Synonym ]:
1H-Pyrrolo[2,3-b]pyridine
7-Aza-7H-indole
3H-Pyrrolo[2,3-b]pyridine
7-Dideazapurine
MFCD00005606
1H-Pyrrolo(2,3-b)pyridine
EINECS 205-981-0
7-Aza-1-pyrindine
1,7-Diazaindene

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
283.1±40.0 °C at 760 mmHg

[ Melting Point ]:
105-107 °C(lit.)

[ Molecular Formula ]:
C₇H₆N₂

[ Molecular Weight ]:
118.14

[ Flash Point ]:
125.0±27.3 °C

[ Exact Mass ]:
118.053101

[ PSA ]:
28.68000

[ LogP ]:
-0.64

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
Refrigerator

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8710000

CHEMICAL NAME :: 1H-Pyrrolo(2,3-b)pyridine

CAS REGISTRY NUMBER :: 271-63-6

LAST UPDATED :: 199501

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H6-N2

MOLECULAR WEIGHT :: 118.15

WISWESSER LINE NOTATION :: T56 BM INJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 490 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,480,1963

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S39-S26-S36/37/39

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
UY8710000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

2-{1H-pyrrolo[2,3-b]pyridin-1-yl}acetic acid
1,3-Dihydro-2H-pyrrolo[2,3-b]pyridin-2-on
BMS-378806
6-Chloro-7-azaindole
methyl 2-oxo-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)acetate
1H-Pyrrolo[2,3-b]pyridin-2-carbaldehyd
4-Iodo-7-azaindole
7-Azaindole-7-oxide
3-(DiMethylaMinoMethyl)-7-azaindole
1H-Pyrrolo[2,3-b]pyridine-2,3-dione

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Selectivity of kinase inhibitor fragments.

J. Med. Chem. 54 , 5131-43, (2011)

A kinase-focused screening set of fragments has been assembled and has proved successful for the discovery of ligand-efficient hits against many targets. Here we present some of our general conclusion...

Synthesis of 7-azaserotonin: its photophysical properties associated with excited state proton transfer reaction.

J. Am. Chem. Soc. 128 , 14426, (2006)

We report the synthesis of 3-(2-aminoethyl)-5-ol-1H-pyrrolo[2,3-b]pyridine (7-azaserotonin), which may potentially serve as an agonist or antagonist of serotonin receptors. In alcohols, the solvent (e...

A practical synthesis of 2-((1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino)-5- fluoronicotinic acid.

J. Org. Chem. 71 , 4021-4023, (2006)

A practical synthesis of a key pharmaceutical intermediate, 2-[(1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino]-5-fluoronicotinic acid (1), is described. To introduce the aminomethyl moiety of 2 via a pal...

1-Boc-7-Azaindole
4-Iodo-7-azaindole
7-Azaindole-7-oxide
6-Cyano-7-azaindole
4-Bromo-7-azaindole
6-Bromo-7-azaindole
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
N-([2,3'-bifuran]-5-ylmethyl)-2-bromobenzenesulfonamide
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(4,4-difluorocyclohexyl)-3-(3,5-dimethyl-1H-pyrazol-4-yl)propanamide
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine