Monomethyl fumarate

Suppliers

Names

[ CAS No. ]:
2756-87-8

[ Name ]:
Monomethyl fumarate

[Synonym ]:
MFCD00063174
(2E)-4-Methoxy-4-oxobut-2-enoic acid
2-Butenedioic acid, monomethyl ester, (2E)-
EINECS 220-412-6
(2E)-4-Methoxy-4-oxo-2-butenoic acid
Methyl Hydrogen Fumarate
2-Butenedioic acid, monomethyl ester
Monomethyl Fumarate
4-Methoxy-4-oxobut-2-enoic acid
Fumaric acid, monomethyl ester

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
250.0±23.0 °C at 760 mmHg

[ Melting Point ]:
144-145ºC

[ Molecular Formula ]:
C5H6O4

[ Molecular Weight ]:
130.099

[ Flash Point ]:
108.9±16.1 °C

[ Exact Mass ]:
130.026611

[ PSA ]:
63.60000

[ LogP ]:
-0.24

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.469

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R41

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Fumaric acid, monomethyl ester
  • Dimethyl fumarate
  • Maleic anhydride
  • Methyl (2E)-2-butenoate
  • Methanol
  • fumaric acid
  • methyl 4-chloro-4-oxobut-2-enoate
  • fumaraldehydic acid methyl ester
  • Maleinaldehydsaeure-methylester
  • Monoethyl fumarate

DownStream

  • 2-Butenoic acid,4-amino-4-oxo-, (2E)-
  • 2H-1,4-Benzothiazine-2-aceticacid, 3,4-dihydro-3-oxo-
  • methyl 2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetate
  • 5-Thiazoleacetic acid,2-amino-4,5-dihydro-4-oxo-
  • methyl 4-chloro-4-oxobut-2-enoate

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.

J. Neuropathol. Exp. Neurol. 74 , 1093-118, (2015)

Despite effective viral suppression through combined antiretroviral therapy (cART), approximately half of HIV-positive individuals have HIV-associated neurocognitive disorders (HAND). Studies of antir...

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

Bioorg. Med. Chem. Lett. 21 , 2736-9, (2011)

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids ...

Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway.

Br. J. Pharmacol. 172 , 3929-43, (2015)

Dimethyl fumarate (DMF) is a newly approved drug for the treatment of relapsing forms of multiple sclerosis and relapsing-remitting multiple sclerosis. Here, we investigated the effects of DMF and its...


More Articles

Related Compounds

  • Monomethyl fumarate D3
  • Monomethyl fumarate-d5
  • sodium monomethyl fumarate
  • monomethyl adenosine 2'-monophosphate
  • monomethyl 2-acetoxy-2-(9-xanthenyl)malonate
  • MONOMETHYL (ETHYLENE GLYCOL)PROPYLTRICHLOROSILANE
  • 5',5'-Dimethyl-4'-(propan-2-yl)-4-azaspiro[bicyclo[2.2.2]octane-2,2'-[1,3]oxazinane]
  • 2,2,5,5-Tetramethyl-4-(propan-2-yl)-1,3-oxazinane
  • 3,3-Dimethyl-4-(propan-2-yl)-1,9-dioxa-5-azaspiro[5.5]undecane
  • 3,3,9,9-Tetramethyl-4-(propan-2-yl)-1-oxa-5-azaspiro[5.5]undecane
  • 1-(2-Cyano-2-propylacetyl)azetidine-2-carboxamide
  • 1-(3-Aminooxolane-2-carbonyl)azetidine-2-carboxamide
  • 4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methanesulfonylbutanamido]but-2-ynoic acid
  • 2-{[(Tert-butoxy)carbonyl]amino}-3-methylhex-5-enoic acid
  • 5-(benzyloxy)-1H-indole-3-sulfonyl fluoride
  • 4-{[2-bromo-5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)phenyl]formamido}but-2-ynoic acid
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