Monomethyl fumarate
Modify Date: 2024-01-02 16:12:15
Monomethyl fumarate structure
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Common Name | Monomethyl fumarate | ||
|---|---|---|---|---|
| CAS Number | 2756-87-8 | Molecular Weight | 130.099 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 250.0±23.0 °C at 760 mmHg | |
| Molecular Formula | C5H6O4 | Melting Point | 144-145ºC | |
| MSDS | Chinese USA | Flash Point | 108.9±16.1 °C | |
| Symbol |
GHS05 |
Signal Word | Danger | |
Use of Monomethyl fumarateMonomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3]. |
| Name | Fumaric Acid Monomethyl Ester |
|---|---|
| Synonym | More Synonyms |
| Description | Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3]. |
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| Related Catalog | |
| In Vitro | Monomethyl fumarate completely inhibits forskolin induced cAMP synthesis with an IC50 of 70 nM. Monomethyl fumarate induces a dose-dependent Ca2+ signal in GPR109A transfected cells with an EC50 of 9.4 μM[1]. Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction[3]. |
| In Vivo | A single dose of Monomethyl fumarate (50-100 mg/kg; IP) before light exposure prevents these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner[2]. Monomethyl fumarate (100 mg/kg) reduces retinal inflammation and oxidative stress. Monomethyl fumarate significantly suppresses light-induced retinopathy (LIR) upregulated genes in the NFkB pathway including: Nlrp3, Casp1, Il-1β, and Tnf-α[2]. Animal Model: Albino BALB/c mice (male, 6 weeks old)[2] Dosage: 50, 65, 75, 100 mg/kg Administration: IP Result: Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 250.0±23.0 °C at 760 mmHg |
| Melting Point | 144-145ºC |
| Molecular Formula | C5H6O4 |
| Molecular Weight | 130.099 |
| Flash Point | 108.9±16.1 °C |
| Exact Mass | 130.026611 |
| PSA | 63.60000 |
| LogP | -0.24 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.469 |
| Symbol |
GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H318 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R41 |
| Safety Phrases | S26-S39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2918990090 |
| Precursor 10 | |
|---|---|
| DownStream 5 | |
CAS#:3052-50-4
CAS#:624-49-7
CAS#:108-31-6
CAS#:623-43-8
CAS#:67-56-1
CAS#:110-17-8
CAS#:17081-97-9
CAS#:5837-72-9
CAS#:57314-32-6
CAS#:2459-05-4
CAS#:2987-87-3
CAS#:6270-74-2
CAS#:7556-63-0
CAS#:33176-41-9| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.
J. Neuropathol. Exp. Neurol. 74 , 1093-118, (2015) Despite effective viral suppression through combined antiretroviral therapy (cART), approximately half of HIV-positive individuals have HIV-associated neurocognitive disorders (HAND). Studies of antir... |
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Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).
Bioorg. Med. Chem. Lett. 21 , 2736-9, (2011) Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids ... |
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Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway.
Br. J. Pharmacol. 172 , 3929-43, (2015) Dimethyl fumarate (DMF) is a newly approved drug for the treatment of relapsing forms of multiple sclerosis and relapsing-remitting multiple sclerosis. Here, we investigated the effects of DMF and its... |
| MFCD00063174 |
| (2E)-4-Methoxy-4-oxobut-2-enoic acid |
| 2-Butenedioic acid, monomethyl ester, (2E)- |
| EINECS 220-412-6 |
| (2E)-4-Methoxy-4-oxo-2-butenoic acid |
| Methyl Hydrogen Fumarate |
| 2-Butenedioic acid, monomethyl ester |
| Monomethyl Fumarate |
| 4-Methoxy-4-oxobut-2-enoic acid |
| Fumaric acid, monomethyl ester |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Monomethyl fumarate
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Monomethyl fumarate
- Price: ￥298.0/1g
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: Monomethyl Fumarate
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Monomethyl fumarate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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