4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE

Suppliers

Names

[ CAS No. ]:
276890-57-4

[ Name ]:
4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE

[Synonym ]:
4-(N-Ethyl-n-4-hydroxybutyl)amino-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidine hydrochloride
4-[ethyll[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol
LWH-63 hydrochloride
NIH-3
4-[ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

Chemical & Physical Properties

[ Molecular Formula ]:
C24H35ClN4O

[ Molecular Weight ]:
431.01400

[ Exact Mass ]:
430.25000

[ PSA ]:
54.18000

[ LogP ]:
5.67170

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (Z)-4-[ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]but-2-en-1-ol
  • N-ethyl-4-hydroxybutanamide

DownStream

Articles

CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists.

Bioorg. Med. Chem. 10 , 175-183, (2002)

A series of compounds related to N-butyl-N-ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine (1, antalarmin) have been prepared and evaluated for their CRHR1 binding af...

Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.

Science 303 , 1512-1514, (2004)

The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobu...


More Articles

Related Compounds

  • tert-butyl N-[4-(2-bromopropyl)-3-fluorophenyl]carbamate
  • (3R,4S)-3,4-difluoropyrrolidine-1-carboxamide
  • 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)but-3-en-2-amine
  • 3-(2-Chloro-5-nitrophenyl)propan-1-amine
  • 3-[5-(4-Methylphenyl)furan-2-yl]propan-1-amine
  • 2-Amino-3-[2-(dimethylamino)pyridin-3-yl]propanoic acid
  • 4-(azetidin-2-yl)-N,N-diethylaniline
  • 3-chloro-4-(1H-pyrazol-4-yl)aniline
  • tert-butyl N-[4-(3-aminobutyl)-2-methoxyphenyl]carbamate
  • tert-butyl N-{2-amino-1-[3-(difluoromethoxy)phenyl]ethyl}carbamate
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