4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE

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Names

[ CAS No. ]:
276890-57-4

[ Name ]:
4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE

[Synonym ]:
4-(N-Ethyl-n-4-hydroxybutyl)amino-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidine hydrochloride
4-[ethyll[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol
LWH-63 hydrochloride
NIH-3
4-[ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

Chemical & Physical Properties

[ Molecular Formula ]:
C24H35ClN4O

[ Molecular Weight ]:
431.01400

[ Exact Mass ]:
430.25000

[ PSA ]:
54.18000

[ LogP ]:
5.67170

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (Z)-4-[ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]but-2-en-1-ol
  • N-ethyl-4-hydroxybutanamide

DownStream

Articles

CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists.

Bioorg. Med. Chem. 10 , 175-183, (2002)

A series of compounds related to N-butyl-N-ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine (1, antalarmin) have been prepared and evaluated for their CRHR1 binding af...

Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.

Science 303 , 1512-1514, (2004)

The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobu...


More Articles

Related Compounds

  • N-(butan-2-yl)-6-(2-methoxyethyl)pyrimidin-4-amine
  • N-cyclopropyl-6-(2-methoxyethyl)pyrimidin-4-amine
  • 4-(Cyclopent-3-en-1-yl)-6-(piperazin-1-yl)pyrimidine
  • N-(2-bromoethyl)-6-(cyclopent-3-en-1-yl)pyrimidin-4-amine
  • 4-methyl-N-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-1-propan-2-ylpyrazol-3-amine;hydrochloride
  • 4-{[6-(Oxan-4-yl)pyrimidin-4-yl]amino}butanoic acid
  • N-(2-bromoethyl)-6-(oxan-4-yl)pyrimidin-4-amine
  • 1-[6-(Oxan-4-yl)pyrimidin-4-yl]pyrrolidin-3-ol
  • 6-(oxan-4-yl)-N-(prop-2-yn-1-yl)pyrimidin-4-amine
  • (3-Fluorooxolan-3-yl)methanesulfonyl chloride
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