DABCO
Suppliers
Names
[ CAS No. ]:
280-57-9
[ Name ]:
DABCO
[Synonym ]:
T66 A B CN FNTJ
UNII-X8M57R0JS5
1,4-diazabicyclo-[2.2.2]octane
dabco33lv
1,4-Diazabicyclo[2.2.2]octane
1,4-diazabicyclo-[2.2.2]-octane
DABCO
TEDA-L33
diazabicyclooctane
1,4-diazabicyclo(2.2.2) octane
TED
BACO
1,4-diaza-bicyclo[2.2.2]octane
teda
triethylenediamine
Triethylene diamine
dabcoeg
EINECS 205-999-9
MFCD00006689
dabcos-25
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
174.0±0.0 °C at 760 mmHg
[ Melting Point ]:
156-159 °C(lit.)
[ Molecular Formula ]:
C6H12N2
[ Molecular Weight ]:
112.17
[ Flash Point ]:
62.2±0.0 °C
[ Exact Mass ]:
112.100044
[ PSA ]:
6.48000
[ LogP ]:
-0.85
[ Vapour Pressure ]:
1.2±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.561
[ Storage condition ]:
2-8°C
[ Stability ]:
Stable, but very hygroscopic. Incompatible with strong oxidizing agents, strong acids. Highly flammable.
[ Water Solubility ]:
46 g/100 mL (26 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HM0354200
- CHEMICAL NAME :
- 1,4-Diazabicyclo(2,2,2)octane
- CAS REGISTRY NUMBER :
- 280-57-9
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C6-H12-N2
- MOLECULAR WEIGHT :
- 112.20
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,522,1962
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,522,1962 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2250 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4680 mg/kg/26W-I
- TOXIC EFFECTS :
- Behavioral - alteration of classical conditioning Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0905 No. of Facilities: 334 (estimated) No. of Industries: 9 No. of Occupations: 15 No. of Employees: 1710 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0905 No. of Facilities: 1104 (estimated) No. of Industries: 23 No. of Occupations: 30 No. of Employees: 33913 (estimated) No. of Female Employees: 5787 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335-H412
[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable
[ Risk Phrases ]:
R11;R22;R36/38;R41;R52/53
[ Safety Phrases ]:
S26-S60-S37/39-S3-S16-S36/37
[ RIDADR ]:
UN 1325 4.1/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
HM0354200
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
29335920
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Stroke 46(3) , 835-42, (2015)
Ischemic stroke has been shown to cause hypermetabolism of glucose in the ischemic penumbra. Experimental and clinical data indicate that infarct-related systemic hyperglycemia is a potential therapeu...
J. Immunol. 194(5) , 2079-88, (2015)
Dendritic cells (DCs) are specialized APCs with the ability to prime naive T cells. DCs first sample Ags from the environment and then orchestrate their processing and loading onto MHC class II (MHC I...
J. Virol. 89(1) , 443-53, (2014)
During DNA encapsidation, herpes simplex virus 1 (HSV-1) procapsids are converted to DNA-containing capsids by a process involving activation of the viral protease, expulsion of the scaffold proteins,...