2,6-Difluorophenol

Names

[ Name ]:
2,6-Difluorophenol

[Synonym ]:
Phenol, 2,6-difluoro-
QR BF FF
2,6-Difluoro phenol
MFCD00002158
2,6-Difluor-phenol
2,6-F2C6H3OH
EINECS 248-884-9
2,6-Difluorophenol

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
157.6±0.0 °C at 760 mmHg

[ Melting Point ]:
38-41 °C(lit.)

[ Molecular Formula ]:
C₆H₄F₂O

[ Molecular Weight ]:
130.092

[ Flash Point ]:
58.9±0.0 °C

[ Exact Mass ]:
130.023026

[ PSA ]:
20.23000

[ LogP ]:
1.98

[ Vapour Pressure ]:
2.1±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.496

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H228-H315-H319-H335

[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
UN 1325 4.1/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
4.1

[ HS Code ]:
2908199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

3,5-Difluoro-4-methoxyaniline
1,3-Difluoro-2-methoxybenzene
4-Bromo-2,5-difluorophenol
2,6-Difluoro-4-Nitroanisole
Thianthrene, 5-oxide
5-(4-hydroxy-3,5-di-fluorophenyl)thianthreniumyl perchlorate
Thianthrene
3-Nitrophenol
(2,6-difluorophenyl) acetate
2-Chloro-4-nitrophenol

Customs

[ HS Code ]: 2908199090

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

Articles

Analysis of the association of cobalt(III) chelates with fluorine-containing phenols in supercritical carbon dioxide.

Talanta 146 , 789-94, (2015)

The solubilities of several cobalt(III) chelates (CoL3) with in supercritical carbon dioxide (SC-CO2) were investigated in the presence of fluorine- and trifluoromethyl-substituted phenols (PhOH) usin...

2,6-Difluorophenol as a bioisostere of a carboxylic acid: bioisosteric analogues of gamma-aminobutyric acid.

J. Med. Chem. 42(2) , 329-32, (1999)

3-(Aminomethyl)-2,6-difluorophenol (6) and 4-(aminomethyl)-2, 6-difluorophenol (7) were synthesized in eight and four steps, respectively, starting from 2,6-difluorophenol, to test the potential of th...

Oxidative Polymerization of 2,6-Difluorophenol to Crystalline Poly(2,6-difluoro-1,4-phenylene oxide). Ikeda R, et al.

Macromolecules 33(18) , 6648-52, (2000)