Sorafenib

Suppliers

Names

[ CAS No. ]:
284461-73-0

[ Name ]:
Sorafenib

[Synonym ]:
SORAFENIB TOLSYLATE
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
MFCD08235032
Bay 43-9006
Forafenib
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
Sorafenib Free Base
Sorafenib
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methyl-2-pyridinecarboxamide
BAY-43-900
Nexavar

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
523.3±50.0 °C at 760 mmHg

[ Melting Point ]:
202-204°C

[ Molecular Formula ]:
C21H16ClF3N4O3

[ Molecular Weight ]:
464.825

[ Flash Point ]:
270.3±30.1 °C

[ Exact Mass ]:
464.086304

[ PSA ]:
92.35000

[ LogP ]:
5.16

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Storage condition ]:
-20°C Freezer

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S37/39

[ WGK Germany ]:
2

[ RTECS ]:
HM1650000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(4-Aminophenoxy)-N-methylpicolinamide
  • 4-Chloro-3-(trifluoromethyl)phenylisocyanate
  • N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide
  • Phenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate
  • 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-hydroxyphenyl)urea
  • N-Methyl-4-chloropyridine-2-carboxamide
  • N-[4-Chloro-3-(trifluoromethyl)phenyl]urea
  • 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxyurea
  • N-methyl-4-(4-(2,2,2-trichloroacetamido)phenoxy)picolinamide
  • 5-Amino-2-chlorobenzotrifluoride

DownStream

  • Sorafenib N-Oxide

Related Compounds

  • Sorafenib
  • Sorafenib-d3
  • Sorafenib-d4
  • Sorafenib N-Oxide
  • Sorafenib Tosylate
  • Sorafenib IMpurity
  • 3-(2-Chloro-6-methylphenyl)-1,1,1-trifluoropropan-2-amine
  • 4-{4-[(trifluoromethyl)sulfanyl]phenyl}-1H-imidazole
  • 3-({4-[(Trifluoromethyl)sulfanyl]phenyl}methyl)pyrrolidin-3-ol
  • (2,2-Dimethyl-1-{4-[(trifluoromethyl)sulfanyl]phenyl}cyclopropyl)methanol
  • 3-{[3-Chloro-4-(trifluoromethyl)phenyl]methyl}pyrrolidine
  • 3-Amino-2-[3-chloro-4-(trifluoromethyl)phenyl]propan-1-ol
  • 2-Azido-2-[3-chloro-4-(trifluoromethyl)phenyl]ethan-1-ol
  • 1-{[3-Chloro-4-(trifluoromethyl)phenyl]methyl}cyclopropane-1-carboxylic acid
  • 2-(3-Chloro-2,4-difluorophenyl)-2,2-difluoroethan-1-ol
  • 3-{[3-Methoxy-4-(trifluoromethyl)phenyl]methyl}azetidin-3-ol
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