7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate

[ Density]:
1.45 g/cm3

[ Boiling Point ]:
524.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₂Cl₂N₂O₃

[ Molecular Weight ]:
363.19500

[ Flash Point ]:
270.9ºC

[ Exact Mass ]:
362.02200

[ PSA ]:
67.76000

[ LogP ]:
3.24570

[ Vapour Pressure ]:
4.33E-11mmHg at 25°C

[ Index of Refraction ]:
1.656

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P273-P501

[ RIDADR ]:
UN 3077 9 / PGIII

Click to get detail synthetic route

Precursor

DownStream

Stereoselective binding of 3-acetoxy-, and 3-hydroxy-1,4-benzodiazepine-2-ones to human serum albumin. Selective allosteric interaction with warfarin enantiomers.

Biochem. Pharmacol. 35(2) , 263-9, (1986)

Stereoselective binding of oxazepam, lorazepam, temazepam and methyl lorazepam as well as of their acetates to human serum albumin was investigated by different techniques. The 2'-chlorine and the N(1...

Stereoselective kinetics of warfarin binding to human serum albumin: effect of an allosteric interaction.

Chirality 14(5) , 442-8, (2002)

Kinetic and equilibrium binding studies were performed on the interaction of warfarin enantiomers with human serum albumin (HSA) in the absence and presence of lorazepam acetate (LoAc) enantiomers. Bi...

Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate.

Chirality 11(2) , 115-20, (1999)

The effect of ibuprofen enantiomers on the stereoselective binding of 3-acyloxy-1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lo...

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