Rosuvastatin

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Names

[ Name ]:
Rosuvastatin

[Synonym ]:
Reference source: Negwer
volume-3 compound no
ROSUVASTATIN-D3 SODIUM SALT
7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid
6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl-d(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, sodium salt, (3R,5S,6E)- (1:1)
[3H]-Rosuvastatin
Rosuvastatin
Sodium (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[(H)methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
MFCD08460959

Chemical & Physical Properties

[ Density]:
1.368 g/cm3

[ Boiling Point ]:
745.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₈FN₃O₆S

[ Molecular Weight ]:
481.54

[ Flash Point ]:
404.7ºC

[ PSA ]:
152.13000

[ LogP ]:
2.14780

[ Vapour Pressure ]:
2.38E-23mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Rosuvastatin methanamine salt
5-Oxorosuvastatin Methyl Ester
tert-butyl 2-[6-[(E)-2-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]ethenyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-heptenoic acid iso-propylammonium salt
tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Rosuvastatin methyl ester
tert-Butyl rosuvastatin
Rosuvastatin ethyl ester
N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide