1H-Indole-2-carboxamide,5-methoxy-N,N-dimethyl-

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Names

[ CAS No. ]:
28837-74-3

[ Name ]:
1H-Indole-2-carboxamide,5-methoxy-N,N-dimethyl-

[Synonym ]:
N,N-Dimethyl-5-methoxyindole-2-carboxamide
Indole-2-carboxamide,N,N-dimethyl-5-methoxy
5-methoxy-indole-2-carboxylic acid dimethylamide

Chemical & Physical Properties

[ Density]:
1.204g/cm3

[ Boiling Point ]:
429.8ºC at 760mmHg

[ Molecular Formula ]:
C12H14N2O2

[ Molecular Weight ]:
218.25200

[ Flash Point ]:
213.8ºC

[ Exact Mass ]:
218.10600

[ PSA ]:
45.33000

[ LogP ]:
1.87830

[ Vapour Pressure ]:
1.36E-07mmHg at 25°C

[ Index of Refraction ]:
1.619

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL5994488
CHEMICAL NAME :
Indole-2-carboxamide, N,N-dimethyl-5-methoxy-
CAS REGISTRY NUMBER :
28837-74-3
BEILSTEIN REFERENCE NO. :
0398307
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H14-N2-O2
MOLECULAR WEIGHT :
218.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJOCAP Indian Journal of Chemistry. (New Delhi, India) V.1-13, 1963-75. Divided into Indian Journal of Chemistry, Section A and Indian Journal of Chemistry, Section B. Volume(issue)/page/year: 8,704,1970

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-methoxyindole-2-carboxylic acid
  • Dimethylamine
  • 1H-Indole-2-carbonyl chloride, 5-methoxy- (9CI)

DownStream

  • 3-formyl-5-methoxy-N,N-dimethyl-1H-indole-2-carboxamide

Related Compounds

  • 1H-Indole-2-carboxamide, 5-chloro-N,N-dimethyl
  • 1H-Indole-2-carboxamide,N,N-dimethyl-
  • 3-formyl-5-methoxy-N,N-dimethyl-1H-indole-2-carboxamide
  • N,N-diethyl-5-methoxy-1H-indole-2-carboxamide
  • N-methyl-N-[2-[methyl-[3-(propan-2-ylamino)pyridin-2-yl]amino]ethyl]-1H-indole-2-carboxamide
  • 1H-Indole-2-carboxamide, 5-Methoxy-
  • 2-Cyano-3-(difluoromethyl)-6-methoxyisonicotinamide
  • 2-Chloro-5-(difluoromethyl)-6-fluoronicotinic acid
  • 6-Chloro-5-(difluoromethyl)-3-(trifluoromethoxy)picolinic acid
  • 3-(Difluoromethyl)-4-formyl-5-(trifluoromethoxy)picolinonitrile
  • 2-(6-Amino-4-(difluoromethyl)-5-methoxypyridin-2-yl)acetonitrile
  • 2-Chloro-5-(difluoromethyl)-3-iodo-6-(trifluoromethoxy)pyridine
  • Benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate
  • 2-Cyano-5-(difluoromethyl)-4-iodobenzoic acid
  • 2-(4,6-Diamino-5-(difluoromethyl)pyridin-3-yl)acetonitrile
  • 6-Amino-2-bromo-5-(difluoromethyl)nicotinamide
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