Sodium L-pyroglutamate

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Names

[ CAS No. ]:
28874-51-3

[ Name ]:
Sodium L-pyroglutamate

[Synonym ]:
sodium pyrrolidonecarboxylate
Sodium L-pyroglutama
Sodium (2S)-5-oxo-2-pyrrolidinecarboxylate
sodium L-pyrrolidone carboxylate
SODIUMPYROGLUTAMICACID
Sodium 5-oxo-2-pyrrolidinecarboxylate
Proline, 5-oxo-, sodium salt (1:1)
L-Proline, 5-oxo-, sodium salt (1:1)
sodium (2S)-5-oxopyrrolidine-2-carboxylate
L-PCA-NA
EINECS 249-277-1
Sodium PCA
Sodium pyroglutamate
dium L-pyroglutamate
L-PCA-Na=SodiumPCA
sodium 5-oxo-L-prolinate
SodiumL-pyroglutamate
UNII:469OTG57A2
Proline, 5-oxo-, monosodium salt
sodium salt of pyroglutamic acid
5-Oxoproline sodium salt

Chemical & Physical Properties

[ Density]:
1.45

[ Boiling Point ]:
453.1ºC at 760 mmHg

[ Melting Point ]:
125ºC

[ Molecular Formula ]:
C5H6NNaO3

[ Molecular Weight ]:
151.096

[ Flash Point ]:
227.8ºC

[ Exact Mass ]:
151.024536

[ PSA ]:
69.23000

[ Vapour Pressure ]:
1.79E-09mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TW4000000
CHEMICAL NAME :
L-Proline, 5-oxo-, monosodium salt
CAS REGISTRY NUMBER :
28874-51-3
LAST UPDATED :
199504
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C5-H7-N-O3.Na

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
364 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,717,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
690 gm/kg/26W-C
TOXIC EFFECTS :
Cardiac - changes in heart weight Liver - changes in liver weight Related to Chronic Data - changes in testicular weight
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,717,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2456 No. of Facilities: 190 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 4559 (estimated) No. of Female Employees: 3989 (estimated)

Safety Information

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • L-(+)Sodium glutamate

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Related Compounds

  • sodium,3,3-dimethyl-7-oxo-6-(2-phenoxybutanoylamino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • (S)-Pyrrolidine-2-carboxylic acid, sodium salt
  • sodium L-α-aminoimidazole-4-propionate
  • Sodium L-lactate-1-13C solution
  • sodium L-glutamate
  • Sodium L-Rhamnonate
  • 3-(Aminomethyl)-3-(2-methylbutan-2-yl)cyclobutan-1-ol
  • (1S)-3-amino-1-(3-chloropyridin-4-yl)propan-1-ol
  • 2-[(Dimethylamino)methyl]-4-[1-(hydroxymethyl)cyclopropyl]phenol
  • (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-(oxan-2-yl)propanoic acid
  • methyl 1-methyl-5-(prop-2-yn-1-yl)-1H-pyrrole-2-carboxylate
  • 2-(1-ethyl-1H-pyrazol-5-yl)prop-2-enoic acid
  • (2S)-2-amino-2-(4-hydroxyoxolan-3-yl)acetic acid
  • 2-[2-(azetidin-3-yl)ethyl]-1H-1,3-benzodiazole
  • Ethyl 3,4-difluoro-2-isopropoxybenzoate
  • 2,4-Dichloro-5-(piperidin-3-yloxy)pyridine
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