Pyrimidine

Names

[ CAS No. ]:
289-95-2

[ Name ]:
Pyrimidine

[Synonym ]:
iazine
Miazine
Pyrimidin
EINECS 206-026-0
PyriMidine free base
1,3-DIAZINE
1,3-Diazin
Metadiazine
m-Diazine
Pyrimidine
MFCD00006059

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
122.4±9.0 °C at 760 mmHg

[ Melting Point ]:
19-22 °C(lit.)

[ Molecular Formula ]:
C₄H₄N₂

[ Molecular Weight ]:
80.088

[ Flash Point ]:
31.1±0.0 °C

[ Exact Mass ]:
80.037445

[ PSA ]:
25.78000

[ LogP ]:
-0.33

[ Vapour Pressure ]:
16.8±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.503

[ Storage condition ]:
Flammables area

[ Stability ]:
Stable, but air-sensitive and hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents, carbon dioxide. Flammable.

[ Water Solubility ]:
soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV6263000

CHEMICAL NAME :: Pyrimidine

CAS REGISTRY NUMBER :: 289-95-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C4-H4-N2

MOLECULAR WEIGHT :: 80.10

WISWESSER LINE NOTATION :: T6N CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 150 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7311 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

Safety Information

[ Symbol ]:

GHS02

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R10

[ Safety Phrases ]:
S23-S24/25-S16

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
UV6263000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

5-Bromopyrimidine
4-Chloropyrimidine
pyrimidinethione
1H-Pyrazole-1-carboximidamide hydrochloride
2,4-Dichloro-5-nitropyrimidine
methylpiperazine
4-Fluoro-3-(trifluoromethyl)phenol
4,6-Difluoropyrimidine
N,N-Carbonyldiimidazole
1-methoxy-1H-pyrimidine-2,4-dione

DownStream

4-(Hydroxymethyl)pyrimidine
5-Phenylpyrimidine
Pyrimidine, 4-phenyl-
2-Phenylpyrimidine
Pyrimidine-5-boronic acid pinacol ester
4-Methylpyrimidine
2-Methylpyrimidine
Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI)
4,6-DIMETHYLPYRIMIDINE
Pyrimidine, 2,4,6-trimethyl- (6CI,7CI,8CI,9CI)

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Assessing the metabolic impact of nitrogen availability using a compartmentalized maize leaf genome-scale model.

Plant Physiol. 166(3) , 1659-74, (2014)

Maize (Zea mays) is an important C4 plant due to its widespread use as a cereal and energy crop. A second-generation genome-scale metabolic model for the maize leaf was created to capture C4 carbon fi...

Orthovanadate-Induced Vasoconstriction of Rat Mesenteric Arteries Is Mediated by Rho Kinase-Dependent Inhibition of Myosin Light Chain Phosphatase.

Biol. Pharm. Bull. 38 , 1809-16, (2015)

Orthovanadate (OVA), a protein tyrosine phosphatase inhibitor, induces vasoconstriction in a Rho kinase-dependent manner. The aim of this study was to determine the mechanism underlying OVA-induced va...

Cetuximab-induced insulin-like growth factor receptor I activation mediates cetuximab resistance in gastric cancer cells.

Mol. Med. Report. 11 , 4547-54, (2015)

Epidermal growth factor receptor (EGFR) and insulin‑like growth factor receptor‑I (IGF‑IR) are frequently overexpressed in gastric cancer cells. However, these cells are resistant to the anti‑EGFR mon...

Pyrimidine
Pyrimidine
bipyrimidine
oxypyrimidine
antipyrimidine
Pyrimidinetriol
Benzyl 2-(hydroxymethyl)-3-oxo-1,2,3,4-tetrahydroquinoxaline-1-carboxylate
benzyl N-(7-hydroxy-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)carbamate
3-[4-(Methoxycarbonyl)-5-methylfuran-2-yl]propanoic acid
(9H-fluoren-9-yl)methyl 4-(2-hydroxypropyl)piperazine-1-carboxylate
(9H-fluoren-9-yl)methyl N-[(3-ethoxy-4-hydroxyphenyl)methyl]carbamate
(9H-fluoren-9-yl)methyl N-[3-(3,4-difluorophenoxy)-2-hydroxypropyl]carbamate
(9H-fluoren-9-yl)methyl N-[2-(diethylamino)ethyl]-N-[2-(2-hydroxyethoxy)ethyl]carbamate
(9H-fluoren-9-yl)methyl N-{4-[(3-hydroxypropyl)sulfanyl]phenyl}carbamate
(9H-fluoren-9-yl)methyl N-{[1-(2-hydroxyethyl)piperidin-4-yl]methyl}-N-methylcarbamate
(9H-fluoren-9-yl)methyl 4-[(2-hydroxyethyl)(methyl)amino]piperidine-1-carboxylate

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