Prednisolone hemisuccinate

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Names

[ CAS No. ]:
2920-86-7

[ Name ]:
Prednisolone hemisuccinate

[Synonym ]:
MFCD00056465
PREDNISOLONE HEMISUCCINATE
PREDNISOLONE 21-HEMISUCCINATE
prednisolone21-succinate
prednisolonbisuccinat
EINECS 220-861-8
prednisolut
prednisolon hemisuccinate
Prednisolone hemisuccinate (usp)
prednisolonebisuccinate
Prednisolone (hemisuccinate)

Chemical & Physical Properties

[ Density]:
0,86 g/cm3

[ Boiling Point ]:
358 °C400 mm Hg(lit.)

[ Melting Point ]:
28-32 °C(lit.)

[ Molecular Formula ]:
C25H32O8

[ Molecular Weight ]:
460.51700

[ Flash Point ]:
265°C/15mm

[ Exact Mass ]:
460.21000

[ PSA ]:
138.20000

[ LogP ]:
1.97330

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.6

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4153400
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(hydrogen succinate)
CAS REGISTRY NUMBER :
2920-86-7
LAST UPDATED :
199504
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C25-H32-O8
MOLECULAR WEIGHT :
460.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
50 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,216,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
75 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,216,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9553 No. of Facilities: 403 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4029 (estimated) No. of Female Employees: 2015 (estimated)

Safety Information

[ Risk Phrases ]:
61-40

[ Safety Phrases ]:
S53-S22-S36/37/39-S45

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
TU4153400

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Succinic anhydride
  • prednisolone
  • (5-nitrothien-2-yl)methyl prednisolone-21-yl butanedioate

DownStream

  • prednisolone

Related Compounds

  • Methylprednisolone hemisuccinate
  • Prednisolone Acetate
  • Prednisolone tebutate
  • Prednisolone-d4-21-carboxylic Acid Sodium Salt
  • [2-[(8S,9S,10R,11S,13S,14S,17R)-17-acetyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • ethyl [(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] carbonate
  • 5-Amino-2-(4-(4-fluorophenyl)piperazin-1-yl)benzamide
  • 2-(4-Chlorobenzyl)oxazolo[4,5-c]pyridine
  • 4-(sec-Butoxy)-3-methoxybenzamide
  • 3-Allyl-4-(benzyloxy)-5-methoxybenzamide
  • 3-Allyl-4-(benzyloxy)-5-methoxybenzohydrazide
  • 3-Bromo-4-isopropoxybenzohydrazide
  • [2-(4-Fluorophenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methanamine
  • 2-Chloro-4-methoxy-6-methylpyrimidin-5-amine
  • N,N-dimethyl-4-(3-methyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)aniline
  • 2-Iodo-3-(trifluoromethoxy)nitrobenzene
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