Prednisolone hemisuccinate

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Names

[ CAS No. ]:
2920-86-7

[ Name ]:
Prednisolone hemisuccinate

[Synonym ]:
MFCD00056465
PREDNISOLONE HEMISUCCINATE
PREDNISOLONE 21-HEMISUCCINATE
prednisolone21-succinate
prednisolonbisuccinat
EINECS 220-861-8
prednisolut
prednisolon hemisuccinate
Prednisolone hemisuccinate (usp)
prednisolonebisuccinate
Prednisolone (hemisuccinate)

Chemical & Physical Properties

[ Density]:
0,86 g/cm3

[ Boiling Point ]:
358 °C400 mm Hg(lit.)

[ Melting Point ]:
28-32 °C(lit.)

[ Molecular Formula ]:
C25H32O8

[ Molecular Weight ]:
460.51700

[ Flash Point ]:
265°C/15mm

[ Exact Mass ]:
460.21000

[ PSA ]:
138.20000

[ LogP ]:
1.97330

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.6

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4153400
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(hydrogen succinate)
CAS REGISTRY NUMBER :
2920-86-7
LAST UPDATED :
199504
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C25-H32-O8
MOLECULAR WEIGHT :
460.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
50 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,216,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
75 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,216,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9553 No. of Facilities: 403 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4029 (estimated) No. of Female Employees: 2015 (estimated)

Safety Information

[ Risk Phrases ]:
61-40

[ Safety Phrases ]:
S53-S22-S36/37/39-S45

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
TU4153400

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Succinic anhydride
  • prednisolone
  • (5-nitrothien-2-yl)methyl prednisolone-21-yl butanedioate

DownStream

  • prednisolone

Related Compounds

  • Methylprednisolone hemisuccinate
  • Prednisolone Acetate
  • Prednisolone tebutate
  • Prednisolone-d4-21-carboxylic Acid Sodium Salt
  • [2-[(8S,9S,10R,11S,13S,14S,17R)-17-acetyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • ethyl [(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] carbonate
  • 1-(prop-2-yn-1-yl)-N-{[2-(propan-2-yloxy)phenyl]methyl}piperidine-4-carboxamide
  • 6-(Trifluoromethyl)pyrimidine-4-carbaldehyde
  • (5-Tert-butylpyrimidin-2-YL)methanamine
  • N-({7-methylimidazo[1,2-a]pyridin-2-yl}methyl)-1-(prop-2-yn-1-yl)piperidine-4-carboxamide
  • N-[1-(4-fluorophenoxy)propan-2-yl]-1-(prop-2-yn-1-yl)piperidine-4-carboxamide
  • N-{[2-(2-methoxyethoxy)phenyl]methyl}-1-(prop-2-yn-1-yl)piperidine-4-carboxamide
  • N-[1-(3-methylphenoxy)propan-2-yl]-1-(prop-2-yn-1-yl)piperidine-4-carboxamide
  • N-[1-(2-fluorophenyl)propan-2-yl]-1-(prop-2-yn-1-yl)piperidine-4-carboxamide
  • N-[2-(2,6-dichlorophenyl)ethyl]-1-(prop-2-yn-1-yl)piperidine-4-carboxamide
  • Methyl 5-((1s)-1-amino-2-hydroxyethyl)pyridine-2-carboxylate
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