7-Nitroindazole

Names

[ Name ]:
7-Nitroindazole

[Synonym ]:
1H-Indazole,7-nitro
MFCD00022789
nitro-7 indazole
7-Nitroindazole
7-NI
2H-Indazole, 7-nitro-
7-Nitro-1H-indazole
7-Nitro-2H-indazole
EINECS 220-934-4

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
211.2±23.0 °C at 760 mmHg

[ Melting Point ]:
185-186°C

[ Molecular Formula ]:
C₇H₅N₃O₂

[ Molecular Weight ]:
163.133

[ Flash Point ]:
81.5±22.6 °C

[ Exact Mass ]:
163.038177

[ PSA ]:
74.50000

[ LogP ]:
1.42

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.741

[ Storage condition ]:
−20°C

[ Water Solubility ]:
slightly soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK7962200

CHEMICAL NAME :: 1H-Indazole, 7-nitro-

CAS REGISTRY NUMBER :: 2942-42-9

BEILSTEIN REFERENCE NO. :: 0006809

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H5-N3-O2

MOLECULAR WEIGHT :: 163.15

WISWESSER LINE NOTATION :: T56 BMNJ INW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,169,1986

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319-H351-H360

[ Precautionary Statements ]:
P201-P281-P301 + P310-P305 + P351 + P338-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R60;R40

[ Safety Phrases ]:
S53-S22-S36/37/39-S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
NK7962200

[ Hazard Class ]:
6.1

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Methyl-6-nitroaniline
TERT-BUTYL 7-NITRO-1H-INDAZOLE-1-CARBOXYLATE
salicylaldehyde, 3-nitro-

DownStream

3-Bromo-1H-indazol-7-amine
7-Amino-2-methylindazole
7-AMINO-1-METHYLINDAZOLE
3-bromo-1H-indazole-7-carbonitrile
7-Iodo-1H-indazole
3-Iodo-7-nitro-1H-indazole
3-bromo-1-methyl-7-nitro-indazole
3-Bromo-7-nitro-1H-indazole
3,5-dibromo-7-nitroindazole
1-methyl-7-nitro-indazole

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats.

Neuropharmacology 89 , 87-99, (2014)

It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L...

Tapentadol and nitric oxide synthase systems.

Behav. Pharmacol. 26(3) , 282-8, (2015)

Tapentadol, a new analgesic drug with a dual mechanism of action (μ-opioid receptor agonism and norepinephrine reuptake inhibition), is indicated for the treatment of moderate to severe acute and chro...

Why Small Differences Matter: Elucidation of the Mechanisms Underlying the Transformation of 2OH- and 3OH-Carbamazepine in Contact with Sand Filter Material.

Environ. Sci. Technol. 49 , 10449-56, (2015)

Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large extent in the human body to several metabolites, including 10,11-dihydroxy-10,11-dihydrocarbamazepine (DiOHC...

7-Nitroindazole
3-iodo-7-nitroindazole
1-N-Boc-7-nitroindazole
1-methyl-7-nitroindazole
2-methyl-7-nitroindazole
2-benzyl-7-nitroindazole
(E)-3-(3,4-dichloro-phenyl)-acrylic acid ethyl ester
8-Chloro-1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
[(3S,3aR,4S,6R,6aR,9aR,9bR)-6-hydroxy-3,6,9-trimethyl-2-oxo-3,3a,4,5,6a,7,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] acetate
1-Amino-6-(ethylthio)-3-methyl-1,3,5-triazine-2,4(1H,3H)-dione
1-(Pyrrolidine-1-carbonyl)imidazolidin-2-one
ethyl N-[(benzyloxy)methanethioyl]carbamate
1-(4-Methylphenyl)prop-2-yn-1-one
beta-Alanine, N-[4-[(4-aminophenyl)azo]benzoyl]-(9CI)
3-(chloromethyl)-1,5-dimethyl-1H-pyrazole-4-sulfonyl chloride
10,13-Difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0,3,7]trideca-1(9),10,12-triene hydrochloride

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.