7-Nitroindazole

Modify Date: 2025-08-20 18:05:58

7-Nitroindazole structure	Common Name	7-Nitroindazole
	CAS Number	2942-42-9	Molecular Weight	163.133
	Density	1.5±0.1 g/cm3	Boiling Point	211.2±23.0 °C at 760 mmHg
	Molecular Formula	C₇H₅N₃O₂	Melting Point	185-186°C
	MSDS	Chinese USA	Flash Point	81.5±22.6 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of 7-Nitroindazole

7-Nitroindazole is a selective nNOS inhibitor with antinociceptive and cardiovascular effects. 7-Nitroindazole is a useful tool to evaluate the biological roles of nitric oxide in the central nervous system[1][2].

Name	7-nitro-1H-indazole
Synonym	More Synonyms

Description	7-Nitroindazole is a selective nNOS inhibitor with antinociceptive and cardiovascular effects. 7-Nitroindazole is a useful tool to evaluate the biological roles of nitric oxide in the central nervous system[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Neurological Disease
References	[1]. Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7. [2]. Moore PK, et al. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993 Sep;110(1):219-24.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Neurological Disease

References

[1]. Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7.

[2]. Moore PK, et al. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993 Sep;110(1):219-24.

Density	1.5±0.1 g/cm3
Boiling Point	211.2±23.0 °C at 760 mmHg
Melting Point	185-186°C
Molecular Formula	C₇H₅N₃O₂
Molecular Weight	163.133
Flash Point	81.5±22.6 °C
Exact Mass	163.038177
PSA	74.50000
LogP	1.42
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.741
Storage condition	−20°C
Water Solubility	slightly soluble

7-Nitroindazole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK7962200

CHEMICAL NAME :: 1H-Indazole, 7-nitro-

CAS REGISTRY NUMBER :: 2942-42-9

BEILSTEIN REFERENCE NO. :: 0006809

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H5-N3-O2

MOLECULAR WEIGHT :: 163.15

WISWESSER LINE NOTATION :: T56 BMNJ INW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,169,1986

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H319-H351-H360
Precautionary Statements	P201-P281-P301 + P310-P305 + P351 + P338-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R60;R40
Safety Phrases	S53-S22-S36/37/39-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	NK7962200
Hazard Class	6.1
HS Code	2933990090

2-Methyl-6-nitr...

CAS#:570-24-1

~97%

7-Nitroindazole

CAS#:2942-42-9

Literature: GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop Patent: WO2010/127855 A1, 2010 ; Location in patent: Page/Page column 124; 125 ;

TERT-BUTYL 7-NI...

CAS#:173459-52-4

~98%

7-Nitroindazole

CAS#:2942-42-9

Literature: El Kazzouli, Said; Koubachi, Jamal; Berteina-Raboin, Sabine; Mouaddib, Abderrahim; Guillaumet, Gerald Tetrahedron Letters, 2006 , vol. 47, # 48 p. 8575 - 8577

salicylaldehyde...

CAS#:5274-70-4

~76%

7-Nitroindazole

CAS#:2942-42-9

Literature: Lokhande; Raheem, Abdul; Sabale; Chabukswar; Jagdale Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6890 - 6892

Precursor 3
CAS#:570-24-1 2-Methyl-6-nitr... CAS#:173459-52-4 TERT-BUTYL 7-NI... CAS#:5274-70-4 salicylaldehyde...
DownStream 10
CAS#:316810-90-9 3-Bromo-1H-inda... CAS#:90223-02-2 7-Amino-2-methy... CAS#:41926-06-1 7-AMINO-1-METHY... CAS#:945762-00-5 3-bromo-1H-inda...
CAS#:945761-94-4 7-Iodo-1H-indazole CAS#:864724-64-1 3-Iodo-7-nitro-... CAS#:74209-37-3 3-bromo-1-methy... CAS#:74209-34-0 3-Bromo-7-nitro...
CAS#:74209-35-1 3,5-dibromo-7-n... CAS#:58706-36-8 1-methyl-7-nitr...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats.

Neuropharmacology 89 , 87-99, (2014)

It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L...

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Tapentadol, a new analgesic drug with a dual mechanism of action (μ-opioid receptor agonism and norepinephrine reuptake inhibition), is indicated for the treatment of moderate to severe acute and chro...

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Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large extent in the human body to several metabolites, including 10,11-dihydroxy-10,11-dihydrocarbamazepine (DiOHC...

1H-Indazole,7-nitro

MFCD00022789

nitro-7 indazole

7-Nitroindazole

7-NI

2H-Indazole, 7-nitro-

7-Nitro-1H-indazole

7-Nitro-2H-indazole

EINECS 220-934-4

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7-Nitroindazole

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