Bentazepam

Suppliers

Names

[ Name ]:
Bentazepam

[Synonym ]:
Bentazepam
CI-718
Tiadipone
Thiadipone
1,3,6,7,8,9-Hexahydro-5-phenyl-2H-(1)benzothieno(2,3-e)-1,4-diazepin-2-one
QM-6008
5-phenyl-1,3,6,7,8,9-hexahydro-benzo[4,5]thieno[2,3-e][1,4]diazepin-2-one
Bentazepamum [INN-Latin]
2H-(1)BENZOTHIENO(2,3-e)-1,4-DIAZEPIN-2-ONE,1,3,6,7,8,9-HEXAHYDRO-5-PHENYL

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
532.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₆N₂OS

[ Molecular Weight ]:
296.38700

[ Flash Point ]:
275.9ºC

[ Exact Mass ]:
296.09800

[ PSA ]:
69.70000

[ LogP ]:
2.99000

[ Vapour Pressure ]:
2E-11mmHg at 25°C

[ Index of Refraction ]:
1.733

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL8230000

CHEMICAL NAME :: 2H-(1)Benzothieno(2,3-e)-1,4-diazepin-2-one, 1,3,6,7,8,9-hexahydro-5-phenyl-

CAS REGISTRY NUMBER :: 29462-18-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H16-N2-O-S

MOLECULAR WEIGHT :: 296.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 129 mg/kg/17W-I

TOXIC EFFECTS :: Behavioral - anorexia (human) Behavioral - muscle weakness Liver - liver function tests impaired

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 343,860,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 980 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 630 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

5,6,7,8-tetrahydro-2-methyl-4H-cyclohepta[b]thiophen-4-one
(E)-3-amino-3-phenyl-2-(2-thioxo-cyclohexyl)-acrylonitrile
Glycine ethyl ester hydrochloride

DownStream

Related Compounds

2-Amino-4-(difluoromethoxy)-5-fluorobenzonitrile
2-[(4-fluorophenyl)sulfanyl]-N-{[1-(2-methylpyridin-4-yl)piperidin-4-yl]methyl}acetamide
4-(Oxan-4-yl)-6-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl}pyrimidine
2-Cyclopropyl-4-[4-(pyrimidin-2-yloxymethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrazine
2-cyclopropyl-4-methyl-6-{4-[6-(1H-pyrazol-1-yl)pyridazin-3-yl]piperazin-1-yl}pyrimidine
(5S,7R)-N-(Cyanomethyl)-2-(2-methoxyethyl)-5,7-dimethyl-5,7-dihydro-4H-pyrano[3,4-c]pyrazole-3-carboxamide
Methyl 2-((3-chloropyridin-2-yl)oxy)acetate
N-(2H-1,3-benzodioxol-5-yl)-N'-[(1-methanesulfonyl-4-methoxypiperidin-4-yl)methyl]ethanediamide
N-[(1-Ethoxycyclopentyl)methyl]but-2-ynamide
[(1R,2R)-2-Phenoxycyclopentyl]urea

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