(R)​-​CR8

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Names

[ CAS No. ]:
294646-77-8

[ Name ]:
(R)​-​CR8

[Synonym ]:
(2R)-2-[(9-Isopropyl-6-{[4-(2-pyridinyl)benzyl]amino}-9H-purin-2-yl)amino]-1-butanol
3ddp
CR-8
HMS3229B13
1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2R)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
671.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H29N7O

[ Molecular Weight ]:
431.533

[ Flash Point ]:
359.8±34.3 °C

[ Exact Mass ]:
431.243347

[ PSA ]:
100.78000

[ LogP ]:
2.10

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.664

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-(-)-2-Amino-1-butanol
  • 2-chloro-9-isopropyl-N-[[4-(2-pyridyl)phenyl]methyl]purin-6-amine

DownStream

Articles

Natural product extracts of the Canadian prairie plant, Thermopsis rhombifolia, have anti-cancer activity in phenotypic cell-based assays.

Nat. Prod. Res. 29 , 1026-34, (2015)

Many plant species within the terrestrial ecological zones of Canada have not yet been investigated for anti-cancer activity. We examined the scientific literature describing the endemic flora from th...

Substitutions in the Escherichia coli RNA polymerase inhibitor T7 Gp2 that allow inhibition of transcription when the primary interaction interface between Gp2 and RNA polymerase becomes compromised.

Microbiology 158 , 2753-64, (2012)

The Escherichia coli-infecting bacteriophage T7 encodes a 7 kDa protein, called Gp2, which is a potent inhibitor of the host RNA polymerase (RNAp). Gp2 is essential for T7 phage development. The inter...

Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion.

J. Neuroinflammation 9 , 169, (2012)

Traumatic spinal cord injury (SCI) induces secondary tissue damage that is associated with astrogliosis and inflammation. We previously reported that acute upregulation of a cluster of cell-cycle-rela...


More Articles

Related Compounds

  • (R)​-​CR8 trihydrochloride
  • β-​D-​Glucopyranosiduronic acid, (R)​-​cyanophenylmethyl
  • 2-​Propanesulfinamide, N-​[1-​(2-​fluoro-​5-​nitrophenyl)​ethylidene]​-​2-​methyl-​, [S(R)​]​-
  • 5(S)​-​HPETE
  • Phosphonic acid, (1-​aminoethyl)​-​, diethyl ester, hydrochloride, (R)​- (9CI)
  • (R)-N-Boc-2-aminocyclohexanone