N-Desmethyl Clomipramine Hydrochloride

[ Boiling Point ]:
466ºC at 760 mmHg

[ Melting Point ]:
204-206°C (dec.)

[ Molecular Formula ]:
C₁₈H₂₂Cl₂N₂

[ Molecular Weight ]:
337.28700

[ Flash Point ]:
235.6ºC

[ Exact Mass ]:
336.11600

[ PSA ]:
15.27000

[ LogP ]:
5.44410

[ Vapour Pressure ]:
4.41E-09mmHg at 25°C

[ Storage condition ]:
-20°C Freezer

Click to get detail MSDS

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
7-16-36/37-45

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.

Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000)

Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomiprami...

Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.

J. Affect. Disord. 29(4) , 267-79, (1993)

We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of D...

Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.

Am. J. Vet. Res. 61(1) , 80-5, (2000)

To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages....

More Articles