Arecoline hydrobromide

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Names

[ CAS No. ]:
300-08-3

[ Name ]:
Arecoline hydrobromide

[Synonym ]:
1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure-methylester,Hydrobromid
MFCD00039041
Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide (1:1)
EINECS 206-087-3
Arecaidine methyl ester hydrobromide
methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (1:1)
Arecoline
Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide
ARECOLINE HBr
Methyl 1,2,5,6-Tetrahydro-1-methylnicotinate Hydrobromide
Methyl-1-methyl-1,2,5,6-tetrahydro-3-pyridincarboxylathydrobromid
1-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester,hydrobromide
arecolinium bromide
Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide (1:1)
Arecoline hydrobromide
Taeniolin
Arecoline bromide
1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic Acid Methyl Ester Hydrobromide
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (9CI)
1-Méthyl-1,2,5,6-tétrahydro-3-pyridinecarboxylate de méthyle bromhydrate
Arecoline (hydrobromide)

Chemical & Physical Properties

[ Boiling Point ]:
209ºC at 760mmHg

[ Melting Point ]:
171-175 °C

[ Molecular Formula ]:
C₈H₁₄BrNO₂

[ Molecular Weight ]:
236.106

[ Flash Point ]:
81.1ºC

[ Exact Mass ]:
235.020782

[ PSA ]:
29.54000

[ LogP ]:
1.31730

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
H2O: 0.1 g/mL, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT2275000

CHEMICAL NAME :: Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide

CAS REGISTRY NUMBER :: 300-08-3

LAST UPDATED :: 199012

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H13-N-O2.Br-H

MOLECULAR WEIGHT :: 236.14

WISWESSER LINE NOTATION :: T6N CUTJ A1 CVO1 &EH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 28,681,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 35,75,1929

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#11778

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 28,681,1972

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S45-S38-S36/37/39-S28A

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QT2275000

[ HS Code ]:
29399990

Precursor & DownStream

Precursor

DownStream

Guvacine hydrochloride
Guvacine
Arecaidine
N,N-diethyl-1-methyl-3,6-dihydro-2H-pyridine-5-carboxamide
1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid
Arecaidine hydrochloride
5,6-DIHYDRO-1,3(2H)-PYRIDINEDICARBOXYLIC ACID, 3-METHYL 1-PHENYL ESTER
prop-2-ynyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
Tiagabine
Guvacoline Hydrobromide

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 12-8, (2014)

A rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of arecoline concentration in dog plasma. Plas...

Arecoline is cytotoxic for human endothelial cells.

J. Oral. Pathol. Med. 43(10) , 761-9, (2014)

Oral submucous fibrosis is a pre-malignant fibrotic condition caused by areca nut use and involves reduced mucosal vascularity. Arecoline is the principal areca nut alkaloid and is cytotoxic for epith...