Hydroxyprogesterone acetate
Suppliers
Names
[ CAS No. ]:
302-23-8
[ Name ]:
Hydroxyprogesterone acetate
[Synonym ]:
17-Acetoxyprogesterone
17α-Acetoxyprogesterone
3,20-Dioxopregn-4-en-17-yl acetate
17a-Hydroxy-progesterone acetate
17ALPHA-ACETOXYPROGESTERONE
Prodox acetate
17α-Hydroxy-4-pregnene-3,20-dione 17-acetate
Chlormadinone acetate impurity G
Pregn-4-ene-3,20-dione, 1-(acetyloxy)-
17-Hydroxypregn-4-ene-3,20-dione acetate
EINECS 206-119-6
17-(Acetyloxy)pregn-4-ene-3,20-dione
Pregn-4-ene-3,20-dione, 17-hydroxy-, acetate
Hydroxyprogesterone acetate
Acetoxyprogesterone
Pregn-4-ene-3,20-dione, 17-(acetyloxy)-
ProgesteroneAcetate
3,20-Dioxopregn-4-en-1-yl acetate
17-Hydroxyprogesterone 17α-acetate
4-Pregnen-17α-ol-3,20-dione acetate
MFCD00021156
17-Hydroxyprogesterone acetate
Pregn-4-ene-3,20-dione, 17- (acetyloxy)-
17α-Acetoxy-4-pregnene-3,20-dione
17α-Acetoxy-4-pregnene-3,20-dione
17a-Hydroxyprogesterone Acetate
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
494.3±45.0 °C at 760 mmHg
[ Melting Point ]:
249-250ºC
[ Molecular Formula ]:
C23H32O4
[ Molecular Weight ]:
372.498
[ Flash Point ]:
213.5±28.8 °C
[ Exact Mass ]:
372.230072
[ PSA ]:
60.44000
[ LogP ]:
3.41
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.541
[ Storage condition ]:
Refrigerator
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU5074000
- CHEMICAL NAME :
- Pregn-4-ene-3,20-dione, 17-hydroxy-, acetate
- CAS REGISTRY NUMBER :
- 302-23-8
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C23-H32-O4
- MOLECULAR WEIGHT :
- 372.55
- WISWESSER LINE NOTATION :
- L E5 B666 OV MUTJ A1 E1 FV1 FOV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 72 mg/kg
- SEX/DURATION :
- male 9 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,540,1959
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,150,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 896 mg/kg
- SEX/DURATION :
- female 32 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 80500 ug/kg
- SEX/DURATION :
- female 23 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2500 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
- REFERENCE :
- ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- DOSE :
- 500 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 7,341,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 100 ug/kg
- SEX/DURATION :
- female 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 142,469,1962
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 40 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H351
[ Precautionary Statements ]:
P280
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R40
[ Safety Phrases ]:
22-24/25-45
[ RIDADR ]:
UN 2811 6
[ WGK Germany ]:
3
[ RTECS ]:
TU5074000