Hydroxyprogesterone acetate

Modify Date: 2026-07-01 17:31:49

Hydroxyprogesterone acetate Structure
Hydroxyprogesterone acetate structure
Common Name Hydroxyprogesterone acetate
CAS Number 302-23-8 Molecular Weight 372.498
Density 1.1±0.1 g/cm3 Boiling Point 494.3±45.0 °C at 760 mmHg
Molecular Formula C23H32O4 Melting Point 249-250ºC
MSDS N/A Flash Point 213.5±28.8 °C
Symbol GHS08
GHS08
Signal Word Warning

 Use of Hydroxyprogesterone acetate


17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface[1][2].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name Progesterone Acetate
Synonym More Synonyms

 Hydroxyprogesterone acetate Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface[1][2].
Related Catalog
In Vitro 17α-Hydroxyprogesterone (Delalutin) is not androgenic, and that it, like progesterone and certain other sex steroids, does not alter the development of nonreproductive organs[1].
References

[1]. R E Seegmiller, et al. Evaluation of the teratogenic potential of delalutin (17 alpha-hydroxyprogesterone caproate) in mice. Teratology. 1983 Oct;28(2):201-8.

[2]. Amy-Eunice Furcron, et al. Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface. Am J Obstet Gynecol. 2015 Dec;213(6):846.e1-846.e19.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.1±0.1 g/cm3
Boiling Point 494.3±45.0 °C at 760 mmHg
Melting Point 249-250ºC
Molecular Formula C23H32O4
Molecular Weight 372.498
Flash Point 213.5±28.8 °C
Exact Mass 372.230072
PSA 60.44000
LogP 3.41
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.541
InChIKey VTHUYJIXSMGYOQ-KOORYGTMSA-N
SMILES CC(=O)OC1(C(C)=O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C
Storage condition Refrigerator

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5074000
CHEMICAL NAME :
Pregn-4-ene-3,20-dione, 17-hydroxy-, acetate
CAS REGISTRY NUMBER :
302-23-8
LAST UPDATED :
199206
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C23-H32-O4
MOLECULAR WEIGHT :
372.55
WISWESSER LINE NOTATION :
L E5 B666 OV MUTJ A1 E1 FV1 FOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
72 mg/kg
SEX/DURATION :
male 9 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,540,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,150,1965
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
896 mg/kg
SEX/DURATION :
female 32 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
80500 ug/kg
SEX/DURATION :
female 23 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 7,341,1966
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
100 ug/kg
SEX/DURATION :
female 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 142,469,1962
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
40 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H351
Precautionary Statements P280
Hazard Codes Xn: Harmful;
Risk Phrases R40
Safety Phrases 22-24/25-45
RIDADR UN 2811 6
WGK Germany 3
RTECS TU5074000

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

17-Acetoxyprogesterone
17α-Acetoxyprogesterone
3,20-Dioxopregn-4-en-17-yl acetate
17a-Hydroxy-progesterone acetate
17ALPHA-ACETOXYPROGESTERONE
Prodox acetate
17α-Hydroxy-4-pregnene-3,20-dione 17-acetate
Chlormadinone acetate impurity G
17-Hydroxypregn-4-ene-3,20-dione acetate
EINECS 206-119-6
17-(Acetyloxy)pregn-4-ene-3,20-dione
Pregn-4-ene-3,20-dione, 17-hydroxy-, acetate
Hydroxyprogesterone acetate
Acetoxyprogesterone
ProgesteroneAcetate
3,20-Dioxopregn-4-en-1-yl acetate
17-Hydroxyprogesterone 17α-acetate
4-Pregnen-17α-ol-3,20-dione acetate
MFCD00021156
17-Hydroxyprogesterone acetate
17α-Acetoxy-4-pregnene-3,20-dione
17α-Acetoxy-4-pregnene-3,20-dione
17a-Hydroxyprogesterone Acetate

 Hydroxyprogesterone acetate | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of Progesterone Acetate?
A: CAS number of Progesterone Acetate is 302-23-8.
Q: What is the molecular weight of Progesterone Acetate?
A: Molecular weight of Progesterone Acetate is 372.498.
Q: What is the molecular formula of Progesterone Acetate?
A: Molecular formula of Progesterone Acetate is C23H32O4.
Q: What is the melting point of Progesterone Acetate?
A: Melting point of Progesterone Acetate is 249-250ºC.
Q: What is the safety information for Progesterone Acetate?
A: Safety information for Progesterone Acetate: 22-24/25-45.
Q: What is the English name of Progesterone Acetate?
A: The English name of Progesterone Acetate is Progesterone Acetate.
Q: What is the SMILES notation of Progesterone Acetate?
A: SMILES notation of Progesterone Acetate is CC(=O)OC1(C(C)=O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C.
Q: What are the storage conditions for Progesterone Acetate?
A: Storage conditions for Progesterone Acetate: Refrigerator.
Q: What is the polar surface area (PSA) of Progesterone Acetate?
A: Polar surface area (PSA) of Progesterone Acetate is 60.44000.
Q: What is the boiling point of Progesterone Acetate?
A: Boiling point of Progesterone Acetate is 494.3±45.0 °C at 760 mmHg.

 Hydroxyprogesterone acetatefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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